Quantitation of melphalan in plasma of patients by reversed-phase high-performance liquid chromatography with electrochemical detection

L. Silvestro, I. Viano, C. Baiocchi, G. Saini, F. Marmont, R. Ferro

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

An analytical procedure for the separation and determination of melphalan in human plasma was carried out. A simple high-performance liquid chromatographic method with electrochemical detection was developed taking advantage of the high sensitivity of the electrode redox reaction. The sample pretreatment consisted of a direct extraction of the interferents rather than of melphalan, owing to the difficulty of extraction of the drug, and was very simple, rapid and reproducible.

Lingua originaleInglese
pagine (da-a)443-450
Numero di pagine8
RivistaJournal of Chromatography B: Biomedical Sciences and Applications
Volume563
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - 15 feb 1991
Pubblicato esternamente

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