Abstract
An analytical procedure for the separation and determination of melphalan in human plasma was carried out. A simple high-performance liquid chromatographic method with electrochemical detection was developed taking advantage of the high sensitivity of the electrode redox reaction. The sample pretreatment consisted of a direct extraction of the interferents rather than of melphalan, owing to the difficulty of extraction of the drug, and was very simple, rapid and reproducible.
Lingua originale | Inglese |
---|---|
pagine (da-a) | 443-450 |
Numero di pagine | 8 |
Rivista | Journal of Chromatography B: Biomedical Sciences and Applications |
Volume | 563 |
Numero di pubblicazione | 2 |
DOI | |
Stato di pubblicazione | Pubblicato - 15 feb 1991 |
Pubblicato esternamente | Sì |