Pt(II) complexes with different N-donor aromatic ligands for specific inhibition of telomerase

G Cavigiolio; L Benedetto; Enrico BOCCALERI; Donato COLANGELO; Ilario VIANO; Domenico OSELLA

doi:10.1016/S0020-1693(00)  00114-6

Pt(II) complexes with different N-donor aromatic ligands for specific inhibition of telomerase

G Cavigiolio
, L Benedetto
, Enrico BOCCALERI
, Donato COLANGELO
, Ilario VIANO
, Domenico OSELLA

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A number of cis-dichloroplatinum(II) derivatives containing aromatic N-donor ligands such as pyridine and/or 5-substituted isoquinolines have been synthesized and fully characterized, with particular use of Raman spectroscopy and mass spectrometry. These complexes have been tested for specific inhibition of telomerase, which could represent a selective target for cancer chemotherapy. The screening of such potential drugs has been performed by a biochemical assay on the isolated enzyme. It is noteworthy that the cis-[PtCl₂(pyridine)(5-SO₃H-isoquinoline)] compound exhibited remarkable telomerase inhibition at a concentration as low as 10^-7 M. (C) 2000 Elsevier Science S.A.

Lingua originale	Inglese
pagine (da-a)	61-68
Numero di pagine	8
Rivista	Inorganica Chimica Acta
Volume	305
Numero di pubblicazione	1
DOI	https://doi.org/10.1016/S0020-1693(00) 00114-6
Stato di pubblicazione	Pubblicato - 2000

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10.1016/S0020-1693(00) 00114-6

http://hdl.handle.net/11579/30844

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title = "Pt(II) complexes with different N-donor aromatic ligands for specific inhibition of telomerase",

abstract = "A number of cis-dichloroplatinum(II) derivatives containing aromatic N-donor ligands such as pyridine and/or 5-substituted isoquinolines have been synthesized and fully characterized, with particular use of Raman spectroscopy and mass spectrometry. These complexes have been tested for specific inhibition of telomerase, which could represent a selective target for cancer chemotherapy. The screening of such potential drugs has been performed by a biochemical assay on the isolated enzyme. It is noteworthy that the cis-[PtCl2(pyridine)(5-SO3H-isoquinoline)] compound exhibited remarkable telomerase inhibition at a concentration as low as 10-7 M. (C) 2000 Elsevier Science S.A.",

author = "G Cavigiolio and L Benedetto and Enrico BOCCALERI and Donato COLANGELO and Ilario VIANO and Domenico OSELLA",

note = "Funding Information: MURST (Rome) is gratefully acknowledged for financial support (ex 60\%). We thank Professor M. Vincenti (Dipartimento di Chimica Analitica, Universit{\`a} di Torino) for recording the MS spectra. ",

year = "2000",

doi = "10.1016/S0020-1693(00) 00114-6",

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TY - JOUR

T1 - Pt(II) complexes with different N-donor aromatic ligands for specific inhibition of telomerase

AU - Cavigiolio, G

AU - Benedetto, L

AU - BOCCALERI, Enrico

AU - COLANGELO, Donato

AU - VIANO, Ilario

AU - OSELLA, Domenico

N1 - Funding Information: MURST (Rome) is gratefully acknowledged for financial support (ex 60%). We thank Professor M. Vincenti (Dipartimento di Chimica Analitica, Università di Torino) for recording the MS spectra.

PY - 2000

Y1 - 2000

N2 - A number of cis-dichloroplatinum(II) derivatives containing aromatic N-donor ligands such as pyridine and/or 5-substituted isoquinolines have been synthesized and fully characterized, with particular use of Raman spectroscopy and mass spectrometry. These complexes have been tested for specific inhibition of telomerase, which could represent a selective target for cancer chemotherapy. The screening of such potential drugs has been performed by a biochemical assay on the isolated enzyme. It is noteworthy that the cis-[PtCl2(pyridine)(5-SO3H-isoquinoline)] compound exhibited remarkable telomerase inhibition at a concentration as low as 10-7 M. (C) 2000 Elsevier Science S.A.

AB - A number of cis-dichloroplatinum(II) derivatives containing aromatic N-donor ligands such as pyridine and/or 5-substituted isoquinolines have been synthesized and fully characterized, with particular use of Raman spectroscopy and mass spectrometry. These complexes have been tested for specific inhibition of telomerase, which could represent a selective target for cancer chemotherapy. The screening of such potential drugs has been performed by a biochemical assay on the isolated enzyme. It is noteworthy that the cis-[PtCl2(pyridine)(5-SO3H-isoquinoline)] compound exhibited remarkable telomerase inhibition at a concentration as low as 10-7 M. (C) 2000 Elsevier Science S.A.

UR - https://iris.uniupo.it/handle/11579/30844

U2 - 10.1016/S0020-1693(00) 00114-6

DO - 10.1016/S0020-1693(00) 00114-6

M3 - Article

SN - 0020-1693

VL - 305

SP - 61

EP - 68

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

IS - 1

ER -

Pt(II) complexes with different N-donor aromatic ligands for specific inhibition of telomerase

Abstract

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