Pt(II) complexes with different N-donor aromatic ligands for specific inhibition of telomerase

Giorgio Cavigiolio; Luigina Benedetto; Enrico Boccaleri; Donato Colangelo; Ilario Viano; Domenico Osella

doi:10.1016/S0020-1693(00)00114-6

Pt(II) complexes with different N-donor aromatic ligands for specific inhibition of telomerase

Giorgio Cavigiolio, Luigina Benedetto, Enrico Boccaleri, Donato Colangelo, Ilario Viano, Domenico Osella

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A number of cis-dichloroplatinum(II) derivatives containing aromatic N-donor ligands such as pyridine and/or 5-substituted isoquinolines have been synthesized and fully characterized, with particular use of Raman spectroscopy and mass spectrometry. These complexes have been tested for specific inhibition of telomerase, which could represent a selective target for cancer chemotherapy. The screening of such potential drugs has been performed by a biochemical assay on the isolated enzyme. It is noteworthy that the cis-[PtCl₂(pyridine)(5-SO₃H-isoquinoline)] compound exhibited remarkable telomerase inhibition at a concentration as low as 10^-7 M. (C) 2000 Elsevier Science S.A.

Lingua originale	Inglese
pagine (da-a)	61-68
Numero di pagine	8
Rivista	Inorganica Chimica Acta
Volume	305
Numero di pubblicazione	1
DOI	https://doi.org/10.1016/S0020-1693(00)00114-6
Stato di pubblicazione	Pubblicato - 14 lug 2000

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.1016/S0020-1693(00)00114-6

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{60d07a97d07243efbfa50d7ef490bd60,

title = "Pt(II) complexes with different N-donor aromatic ligands for specific inhibition of telomerase",

abstract = "A number of cis-dichloroplatinum(II) derivatives containing aromatic N-donor ligands such as pyridine and/or 5-substituted isoquinolines have been synthesized and fully characterized, with particular use of Raman spectroscopy and mass spectrometry. These complexes have been tested for specific inhibition of telomerase, which could represent a selective target for cancer chemotherapy. The screening of such potential drugs has been performed by a biochemical assay on the isolated enzyme. It is noteworthy that the cis-[PtCl2(pyridine)(5-SO3H-isoquinoline)] compound exhibited remarkable telomerase inhibition at a concentration as low as 10-7 M. (C) 2000 Elsevier Science S.A.",

keywords = "Antitumor agents, Isoquinoline complexes, Platinum complexes, Telomerase",

author = "Giorgio Cavigiolio and Luigina Benedetto and Enrico Boccaleri and Donato Colangelo and Ilario Viano and Domenico Osella",

note = "Funding Information: MURST (Rome) is gratefully acknowledged for financial support (ex 60%). We thank Professor M. Vincenti (Dipartimento di Chimica Analitica, Universit{\`a} di Torino) for recording the MS spectra. ",

year = "2000",

month = jul,

day = "14",

doi = "10.1016/S0020-1693(00)00114-6",

language = "English",

volume = "305",

pages = "61--68",

journal = "Inorganica Chimica Acta",

issn = "0020-1693",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Pt(II) complexes with different N-donor aromatic ligands for specific inhibition of telomerase

AU - Cavigiolio, Giorgio

AU - Benedetto, Luigina

AU - Boccaleri, Enrico

AU - Colangelo, Donato

AU - Viano, Ilario

AU - Osella, Domenico

N1 - Funding Information: MURST (Rome) is gratefully acknowledged for financial support (ex 60%). We thank Professor M. Vincenti (Dipartimento di Chimica Analitica, Università di Torino) for recording the MS spectra.

PY - 2000/7/14

Y1 - 2000/7/14

N2 - A number of cis-dichloroplatinum(II) derivatives containing aromatic N-donor ligands such as pyridine and/or 5-substituted isoquinolines have been synthesized and fully characterized, with particular use of Raman spectroscopy and mass spectrometry. These complexes have been tested for specific inhibition of telomerase, which could represent a selective target for cancer chemotherapy. The screening of such potential drugs has been performed by a biochemical assay on the isolated enzyme. It is noteworthy that the cis-[PtCl2(pyridine)(5-SO3H-isoquinoline)] compound exhibited remarkable telomerase inhibition at a concentration as low as 10-7 M. (C) 2000 Elsevier Science S.A.

AB - A number of cis-dichloroplatinum(II) derivatives containing aromatic N-donor ligands such as pyridine and/or 5-substituted isoquinolines have been synthesized and fully characterized, with particular use of Raman spectroscopy and mass spectrometry. These complexes have been tested for specific inhibition of telomerase, which could represent a selective target for cancer chemotherapy. The screening of such potential drugs has been performed by a biochemical assay on the isolated enzyme. It is noteworthy that the cis-[PtCl2(pyridine)(5-SO3H-isoquinoline)] compound exhibited remarkable telomerase inhibition at a concentration as low as 10-7 M. (C) 2000 Elsevier Science S.A.

KW - Antitumor agents

KW - Isoquinoline complexes

KW - Platinum complexes

KW - Telomerase

UR - http://www.scopus.com/inward/record.url?scp=0034647428&partnerID=8YFLogxK

U2 - 10.1016/S0020-1693(00)00114-6

DO - 10.1016/S0020-1693(00)00114-6

M3 - Article

SN - 0020-1693

VL - 305

SP - 61

EP - 68

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

IS - 1

ER -

Pt(II) complexes with different N-donor aromatic ligands for specific inhibition of telomerase

Abstract

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo