Pros and cons of bifunctional platinum(iv) antitumor prodrugs: two are (not always) better than one

Elisabetta GABANO; Mauro RAVERA; Domenico OSELLA

doi:10.1039/c4dt00911h

Pros and cons of bifunctional platinum(iv) antitumor prodrugs: two are (not always) better than one

Elisabetta GABANO
, Mauro RAVERA
, Domenico OSELLA

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

This article evaluates the efficacy and applicability of bifunctional prodrugs consisting of a six-coordinate Pt(iv) octahedral core and one or more bioactive molecules. The platinum(iv) complexes release upon reduction the corresponding cytotoxic Pt(ii) agents and the bioactive molecules, able to inhibit some biochemical mechanisms of cancer growth and/or prevent the deactivation of the Pt(ii) metabolites.

Lingua originale	Inglese
pagine (da-a)	9813-9820
Rivista	Dalton Transactions
Volume	43
DOI	https://doi.org/10.1039/c4dt00911h
Stato di pubblicazione	Pubblicato - 2014

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10.1039/c4dt00911h

http://hdl.handle.net/11579/54771

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title = "Pros and cons of bifunctional platinum(iv) antitumor prodrugs: two are (not always) better than one",

abstract = "This article evaluates the efficacy and applicability of bifunctional prodrugs consisting of a six-coordinate Pt(iv) octahedral core and one or more bioactive molecules. The platinum(iv) complexes release upon reduction the corresponding cytotoxic Pt(ii) agents and the bioactive molecules, able to inhibit some biochemical mechanisms of cancer growth and/or prevent the deactivation of the Pt(ii) metabolites.",

author = "Elisabetta GABANO and Mauro RAVERA and Domenico OSELLA",

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AB - This article evaluates the efficacy and applicability of bifunctional prodrugs consisting of a six-coordinate Pt(iv) octahedral core and one or more bioactive molecules. The platinum(iv) complexes release upon reduction the corresponding cytotoxic Pt(ii) agents and the bioactive molecules, able to inhibit some biochemical mechanisms of cancer growth and/or prevent the deactivation of the Pt(ii) metabolites.

UR - https://iris.uniupo.it/handle/11579/54771

U2 - 10.1039/c4dt00911h

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M3 - Article

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EP - 9820

JO - Dalton Transactions

JF - Dalton Transactions

ER -

Pros and cons of bifunctional platinum(iv) antitumor prodrugs: two are (not always) better than one

Abstract

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