TY - JOUR
T1 - Prone Positioning in Patients with COVID-19
T2 - Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data
AU - THE PROPCOR CONSORTIUM-7 INVESTIGATOR SOSAMA ABOU-ARAB, BERNARD ALLAOUCHICHE, ALFREDO J. ASTUA, KALOMOIRA ATHANASIOU, FRANCESCO BARONE-ADESI, DAMIEN BASILLE, CHRISTOPHE BEYLS, EMMANUEL BOSELLI, ATHINA DAPERGOLA, LUCA GRILLENZONI, PRERANA JAIN, ELENI KAKAL
AU - Kollias, Anastasios
AU - Kyriakoulis, Konstantinos G.
AU - Rapti, Vasiliki
AU - Trontzas, Ioannis P.
AU - Nitsotolis, Thomas
AU - Syrigos, Konstantinos
AU - Poulakou, Garyphallia
N1 - Publisher Copyright:
© 2022 International Institute of Anticancer Research. All rights reserved.
PY - 2022/2
Y1 - 2022/2
N2 - Background/Aim: Evidence suggests a beneficial effect of prone positioning (PP) in COVID-19. Materials and Methods: Meta-analysis of individual (7 investigators’ groups) and aggregate data (PubMed/EMBASE) regarding the impact of PP on the ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PO2/FiO2) in patients with COVID-19. Results: Among 121 patients (mean age±SD 59.1±10.7 years, 55% males, 57% intubated) the mean post-versus pre- PP PO2/FiO2 difference was: (i) 50.4±64.3 mmHg, p<0.01, (ii) similar in awake (58.7±72.1 mmHg) versus intubated patients (44.1±57.5 mmHg, p=NS), (iii) inversely correlated with body mass index (r=–0.43, p<0.01). Meta-analysis of 23 studies (n=547, weighted age 58.3±4.1, 73% males, 59% intubated) showed a pooled PO2/FiO2 difference of 61.8 [95% confidence intervals=49.9-73.6] mmHg. Meta-regression analysis revealed no associations with baseline demographics, the time in PP before assessment, and the risk of bias of the studies. Conclusion: PP seems to improve oxygenation of patients with COVID-19.
AB - Background/Aim: Evidence suggests a beneficial effect of prone positioning (PP) in COVID-19. Materials and Methods: Meta-analysis of individual (7 investigators’ groups) and aggregate data (PubMed/EMBASE) regarding the impact of PP on the ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PO2/FiO2) in patients with COVID-19. Results: Among 121 patients (mean age±SD 59.1±10.7 years, 55% males, 57% intubated) the mean post-versus pre- PP PO2/FiO2 difference was: (i) 50.4±64.3 mmHg, p<0.01, (ii) similar in awake (58.7±72.1 mmHg) versus intubated patients (44.1±57.5 mmHg, p=NS), (iii) inversely correlated with body mass index (r=–0.43, p<0.01). Meta-analysis of 23 studies (n=547, weighted age 58.3±4.1, 73% males, 59% intubated) showed a pooled PO2/FiO2 difference of 61.8 [95% confidence intervals=49.9-73.6] mmHg. Meta-regression analysis revealed no associations with baseline demographics, the time in PP before assessment, and the risk of bias of the studies. Conclusion: PP seems to improve oxygenation of patients with COVID-19.
KW - COVID-19
KW - Meta-analysis
KW - Oxygenation
KW - Prone position
KW - Respiratory distress
UR - https://www.scopus.com/pages/publications/85123036735
U2 - 10.21873/INVIVO.12711
DO - 10.21873/INVIVO.12711
M3 - Article
SN - 0258-851X
VL - 36
SP - 361
EP - 370
JO - In Vivo
JF - In Vivo
IS - 1
ER -
