@article{f41a629f0207416a9c5ffcdea9d4c96c,
title = "Promoter for the human ferritin heavy chain-encoding gene (FERH): structural and functional characterization",
abstract = "We conducted a functional analysis of the promoter for the human ferritin heavy chain-encoding gene (pFERH) in HepG2 and HeLa cells. The activity of pFERH is equivalent in both cell types, despite their different ferritin (Fer) isotypes. Transfections of a series of 5′-deletion mutants indicate that pFERH activity is essentially dependent on two motifs. One of them, accounting for about 50% of the total transcriptional activity, is recognized by the RNA polymerase II transcription factor, Sp1, and the other by a low-affinity factor present in both the cell types analyzed.",
keywords = "DNA footprinting, Recombinant DNA, chloramphenicol acetyltransferase assay, gene regulation, transcription factor Sp1",
author = "Bevilacqua, {M. A.} and M. Giordano and P. D'Agostino and C. Santoro and F. Cimino and F. Costanzo",
note = "Funding Information: The authors deeply thank T. Russo for helpful suggestions and for having read the manuscript, and A.R. Mogavero for skillful technical assistance. The plasmid 2x(Adeno CTF/NF1)SV40CAT was a generous gift from A. Riccio. This work was supported by grants from P.F.ln-gegneria Genetica, CNR (Rome) and from Ministero dell'Universit~ e della Ricerca Scientifica e Tecnologica (M.U.R.S.T.) (40~ and 60~).",
year = "1992",
month = feb,
day = "15",
doi = "10.1016/0378-1119(92)90696-M",
language = "English",
volume = "111",
pages = "255--260",
journal = "Gene",
issn = "0378-1119",
publisher = "Elsevier B.V.",
number = "2",
}