Prolactin induces grooming in the rat: Possible involvement of nigrostriatal dopaminergic system

Filippo Drago; Béla Bohus; Pier Luigi Canonico; Umberto Scapagnini

doi:10.1016/0091-3057(81)90339-7

Prolactin induces grooming in the rat: Possible involvement of nigrostriatal dopaminergic system

Filippo Drago, Béla Bohus, Pier Luigi Canonico, Umberto Scapagnini

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The possibility that Proclactin-induced grooming involves the nigrostriatal dopaminergic system was studied. Intracerebroventricular injection of rat Prolactin (PRL) in an amount of 10 μg induced grooming in male rats, and neostriatal injection of haloperidol (1 μg/1 μl) markedly suppressed this effect. Local administration of 6-OHDA in t he substantia nigra also abolished the influence of intracerebroventricularly administered PRL. Bilateral injections of PRL (10 μg/1 μl) in the neostriatum failed to induce grooming, whereas bilateral injections of peptide into the substantia nigra (1 μg/0.5 μl) elicited the behavioral response. It is probable that PRL induces grooming in the rat by interacting with the nigrostriatal dopaminergic transmission through an action on the cell bodies rather than in presynaptic terminals or at the postsynaptic level of this system.

Lingua originale	Inglese
pagine (da-a)	61-63
Numero di pagine	3
Rivista	Pharmacology Biochemistry and Behavior
Volume	15
Numero di pubblicazione	1
DOI	https://doi.org/10.1016/0091-3057(81)90339-7
Stato di pubblicazione	Pubblicato - lug 1981
Pubblicato esternamente	Sì

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title = "Prolactin induces grooming in the rat: Possible involvement of nigrostriatal dopaminergic system",

abstract = "The possibility that Proclactin-induced grooming involves the nigrostriatal dopaminergic system was studied. Intracerebroventricular injection of rat Prolactin (PRL) in an amount of 10 μg induced grooming in male rats, and neostriatal injection of haloperidol (1 μg/1 μl) markedly suppressed this effect. Local administration of 6-OHDA in t he substantia nigra also abolished the influence of intracerebroventricularly administered PRL. Bilateral injections of PRL (10 μg/1 μl) in the neostriatum failed to induce grooming, whereas bilateral injections of peptide into the substantia nigra (1 μg/0.5 μl) elicited the behavioral response. It is probable that PRL induces grooming in the rat by interacting with the nigrostriatal dopaminergic transmission through an action on the cell bodies rather than in presynaptic terminals or at the postsynaptic level of this system.",

keywords = "6-OHDA, Grooming behavior, Haloperidol, Nigrotriatal system, Prolactin",

author = "Filippo Drago and B{\'e}la Bohus and Canonico, {Pier Luigi} and Umberto Scapagnini",

year = "1981",

month = jul,

doi = "10.1016/0091-3057(81)90339-7",

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journal = "Pharmacology Biochemistry and Behavior",

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T1 - Prolactin induces grooming in the rat

T2 - Possible involvement of nigrostriatal dopaminergic system

AU - Drago, Filippo

AU - Bohus, Béla

AU - Canonico, Pier Luigi

AU - Scapagnini, Umberto

PY - 1981/7

Y1 - 1981/7

N2 - The possibility that Proclactin-induced grooming involves the nigrostriatal dopaminergic system was studied. Intracerebroventricular injection of rat Prolactin (PRL) in an amount of 10 μg induced grooming in male rats, and neostriatal injection of haloperidol (1 μg/1 μl) markedly suppressed this effect. Local administration of 6-OHDA in t he substantia nigra also abolished the influence of intracerebroventricularly administered PRL. Bilateral injections of PRL (10 μg/1 μl) in the neostriatum failed to induce grooming, whereas bilateral injections of peptide into the substantia nigra (1 μg/0.5 μl) elicited the behavioral response. It is probable that PRL induces grooming in the rat by interacting with the nigrostriatal dopaminergic transmission through an action on the cell bodies rather than in presynaptic terminals or at the postsynaptic level of this system.

AB - The possibility that Proclactin-induced grooming involves the nigrostriatal dopaminergic system was studied. Intracerebroventricular injection of rat Prolactin (PRL) in an amount of 10 μg induced grooming in male rats, and neostriatal injection of haloperidol (1 μg/1 μl) markedly suppressed this effect. Local administration of 6-OHDA in t he substantia nigra also abolished the influence of intracerebroventricularly administered PRL. Bilateral injections of PRL (10 μg/1 μl) in the neostriatum failed to induce grooming, whereas bilateral injections of peptide into the substantia nigra (1 μg/0.5 μl) elicited the behavioral response. It is probable that PRL induces grooming in the rat by interacting with the nigrostriatal dopaminergic transmission through an action on the cell bodies rather than in presynaptic terminals or at the postsynaptic level of this system.

KW - 6-OHDA

KW - Grooming behavior

KW - Haloperidol

KW - Nigrotriatal system

KW - Prolactin

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U2 - 10.1016/0091-3057(81)90339-7

DO - 10.1016/0091-3057(81)90339-7

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JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

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ER -

Prolactin induces grooming in the rat: Possible involvement of nigrostriatal dopaminergic system

Abstract

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