Progressive multifocal leucoencephalopathy after autologous bone marrow transplantation: A treatment option

P Ripellino; Cristoforo COMI; M Mula; C Varrasi; A Conconi; ALESSANDRO STECCO; D Brustia; N Nasuelli; K Savio; Paoli L De; Roberto CANTELLO; Gianluca GAIDANO; F. Monaco

doi:10.1136/bcr.11.2010.3549

Progressive multifocal leucoencephalopathy after autologous bone marrow transplantation: A treatment option

P Ripellino, Cristoforo COMI, M Mula, C Varrasi, A Conconi, ALESSANDRO STECCO, D Brustia, N Nasuelli, K Savio, Paoli L De, Roberto CANTELLO, Gianluca GAIDANO, F. Monaco

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A patient with multiple myeloma was treated with high-dose chemotherapy followed by two autologous bone marrow transplantations (ABMTs). Nine months after the second ABMT the patient complained of severe left hemiparesis, paraesthesias, left homonymous visual field defects and gait ataxia. She was diagnosed with progressive multifocal leucoencephalopathy (PML) confirmed by detection of JC virus (JCV) DNA and prescribed cidofovir every other week and mirtazapine daily. Her symptoms and signs remained stable and after 6 months the JCV DNA was undetectable in the cerebrospinal fluid. Repeated MRI scans demonstrated the stabilisation of demyelinating lesion volume; after more than 2 years of follow-up the patient's neurological examination does not show significant variations. Combination of cidofovir and mirtazapine may be helpful in the treatment of PML in HIV-negative patients.

Lingua originale	Inglese
Rivista	BMJ CASE REPORT
DOI	https://doi.org/10.1136/bcr.11.2010.3549
Stato di pubblicazione	Pubblicato - 1 gen 2011

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10.1136/bcr.11.2010.3549

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title = "Progressive multifocal leucoencephalopathy after autologous bone marrow transplantation: A treatment option",

abstract = "A patient with multiple myeloma was treated with high-dose chemotherapy followed by two autologous bone marrow transplantations (ABMTs). Nine months after the second ABMT the patient complained of severe left hemiparesis, paraesthesias, left homonymous visual field defects and gait ataxia. She was diagnosed with progressive multifocal leucoencephalopathy (PML) confirmed by detection of JC virus (JCV) DNA and prescribed cidofovir every other week and mirtazapine daily. Her symptoms and signs remained stable and after 6 months the JCV DNA was undetectable in the cerebrospinal fluid. Repeated MRI scans demonstrated the stabilisation of demyelinating lesion volume; after more than 2 years of follow-up the patient's neurological examination does not show significant variations. Combination of cidofovir and mirtazapine may be helpful in the treatment of PML in HIV-negative patients.",

author = "P Ripellino and Cristoforo COMI and M Mula and C Varrasi and A Conconi and ALESSANDRO STECCO and D Brustia and N Nasuelli and K Savio and De, {Paoli L} and Roberto CANTELLO and Gianluca GAIDANO and F. Monaco",

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doi = "10.1136/bcr.11.2010.3549",

language = "English",

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TY - JOUR

T1 - Progressive multifocal leucoencephalopathy after autologous bone marrow transplantation: A treatment option

AU - Ripellino, P

AU - COMI, Cristoforo

AU - Mula, M

AU - Varrasi, C

AU - Conconi, A

AU - STECCO, ALESSANDRO

AU - Brustia, D

AU - Nasuelli, N

AU - Savio, K

AU - De, Paoli L

AU - CANTELLO, Roberto

AU - GAIDANO, Gianluca

AU - Monaco, F.

PY - 2011/1/1

Y1 - 2011/1/1

N2 - A patient with multiple myeloma was treated with high-dose chemotherapy followed by two autologous bone marrow transplantations (ABMTs). Nine months after the second ABMT the patient complained of severe left hemiparesis, paraesthesias, left homonymous visual field defects and gait ataxia. She was diagnosed with progressive multifocal leucoencephalopathy (PML) confirmed by detection of JC virus (JCV) DNA and prescribed cidofovir every other week and mirtazapine daily. Her symptoms and signs remained stable and after 6 months the JCV DNA was undetectable in the cerebrospinal fluid. Repeated MRI scans demonstrated the stabilisation of demyelinating lesion volume; after more than 2 years of follow-up the patient's neurological examination does not show significant variations. Combination of cidofovir and mirtazapine may be helpful in the treatment of PML in HIV-negative patients.

AB - A patient with multiple myeloma was treated with high-dose chemotherapy followed by two autologous bone marrow transplantations (ABMTs). Nine months after the second ABMT the patient complained of severe left hemiparesis, paraesthesias, left homonymous visual field defects and gait ataxia. She was diagnosed with progressive multifocal leucoencephalopathy (PML) confirmed by detection of JC virus (JCV) DNA and prescribed cidofovir every other week and mirtazapine daily. Her symptoms and signs remained stable and after 6 months the JCV DNA was undetectable in the cerebrospinal fluid. Repeated MRI scans demonstrated the stabilisation of demyelinating lesion volume; after more than 2 years of follow-up the patient's neurological examination does not show significant variations. Combination of cidofovir and mirtazapine may be helpful in the treatment of PML in HIV-negative patients.

UR - https://iris.uniupo.it/handle/11579/31419

U2 - 10.1136/bcr.11.2010.3549

DO - 10.1136/bcr.11.2010.3549

M3 - Article

SN - 1757-790X

JO - BMJ CASE REPORT

JF - BMJ CASE REPORT

ER -

Progressive multifocal leucoencephalopathy after autologous bone marrow transplantation: A treatment option

Abstract

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