Prognostic role of pre-diagnostic circulating inflammatory biomarkers in breast cancer survival: evidence from the EPIC cohort study

C. Castro-Espin, M. Cairat, Navionis A. -S., C. C. Dahm, C. S. Antoniussen, A. Tjonneland, L. Mellemkjaer, F. R. Mancini, M. Hajji-Louati, G. Severi, Cornet C. Le, R. Kaaks, M. B. Schulze, G. Masala, C. Agnoli, Carlotta SACERDOTE, M. Crous-Bou, Sanchez M. -J., P. Amiano, Chirlaque M. -D.M. Guevara, K. Smith-Byrne, A. K. Heath, S. Christakoudi, M. J. Gunter, S. Rinaldi, A. Agudo, L. Dossus

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

BackgroundInflammation influences tumour progression and cancer prognosis, but its role preceding breast cancer (BC) and its prognostic implications remain inconclusive. MethodsWe studied pre-diagnostic plasma inflammatory biomarkers in 1538 women with BC from the EPIC study. Cox proportional hazards models assessed their relationship with all-cause and BC-specific mortality, adjusting for tumour characteristics and lifestyle factors. ResultsOver a 7-year follow-up after diagnosis, 229 women died, 163 from BC. Elevated IL-6 levels were associated with increased all-cause mortality risk (HR1-SD 1.25, 95% CI 1.07-1.47). Among postmenopausal, IL-6 was associated with higher all-cause (HR1-SD 1.41, 95% CI 1.18-1.69) and BC-specific mortality (HR1-SD 1.31, 95% CI 1.03-1.66), (PHeterogeneity (pre/postmenopausal) < 0.05 for both), while IL-10 and TNF alpha were associated with all-cause mortality only (HR1-SD 1.19, 95% CI 1.02-1.40 and HR1-SD 1.28, 95% CI 1.06-1.56). Among ER+PR+, IL-10 was associated with all-cause and BC-specific mortality (HR1-SD 1.35, 95% CI 1.10-1.65 and HR1-SD 1.42 95% CI 1.08-1.86), while TNF-alpha was associated with all-cause mortality in HER2- (HR1-SD 1.31, 95% CI 1.07-1.61). An inflammatory score predicted higher all-cause mortality, especially in postmenopausal women (HR1-SD 1.30, 95% CI 1.07-1.58). ConclusionsHigher pre-diagnosis IL-6 levels suggest poorer long-term survival among BC survivors. In postmenopausal survivors, elevated IL-6, IL-10, and TNF alpha and inflammatory scores seem to predict all-cause mortality.
Lingua originaleInglese
pagine (da-a)1496-1505
Numero di pagine10
RivistaBritish Journal of Cancer
Volume131
Numero di pubblicazione9
DOI
Stato di pubblicazionePubblicato - 2024

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