TY - JOUR
T1 - Prognostic role of margin status in open and CO2 laser cordectomy for T1a–T1b glottic cancer
AU - Landolfo, Vincenzo
AU - Gervasio, Carmine Fernando
AU - Riva, Giuseppe
AU - Garzaro, Massimiliano
AU - Audisio, Rita
AU - Pecorari, Giancarlo
AU - Albera, Roberto
N1 - Publisher Copyright:
© 2016 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Introduction: Cordectomy by laringofissure and transoral laser surgery has been proposed for the treatment of early glottic cancer. Objectives: The aim of this retrospective study was to evaluate the prognostic value of margin status in 162 consecutive cases of early glottic carcinoma (Tis–T1) treated with CO2 laser endoscopic surgery (Group A) or laryngofissure cordectomy (Group B), and to compare the oncologic and functional results. Methods: Clinical prognostic factors, local recurrence rate according to margin status, overall survival and disease-free survival were analyzed. Results: Margin status is related to recurrence rate in both groups (p < 0.05) without significant differences between open and laser cordectomy (p > 0.05). The 5 years overall survival and disease-free survival were respectively 90.48% and 85.71% in Group A; 88.14% and 86.44% in Group B (p > 0.05). Lower tracheostomy rate, earlier recovery of swallowing function and shorter hospital stay were observed in Group A (p < 0.05). Conclusions: Margin status has a prognostic role in T1a–T1b glottic cancer. Transoral laser surgery showed similar oncologic results of open cordectomy, with better functional outcomes.
AB - Introduction: Cordectomy by laringofissure and transoral laser surgery has been proposed for the treatment of early glottic cancer. Objectives: The aim of this retrospective study was to evaluate the prognostic value of margin status in 162 consecutive cases of early glottic carcinoma (Tis–T1) treated with CO2 laser endoscopic surgery (Group A) or laryngofissure cordectomy (Group B), and to compare the oncologic and functional results. Methods: Clinical prognostic factors, local recurrence rate according to margin status, overall survival and disease-free survival were analyzed. Results: Margin status is related to recurrence rate in both groups (p < 0.05) without significant differences between open and laser cordectomy (p > 0.05). The 5 years overall survival and disease-free survival were respectively 90.48% and 85.71% in Group A; 88.14% and 86.44% in Group B (p > 0.05). Lower tracheostomy rate, earlier recovery of swallowing function and shorter hospital stay were observed in Group A (p < 0.05). Conclusions: Margin status has a prognostic role in T1a–T1b glottic cancer. Transoral laser surgery showed similar oncologic results of open cordectomy, with better functional outcomes.
KW - Disease free survival
KW - Early glottic cancer
KW - Laryngeal neoplasms
KW - Margin status
KW - Overall survival
UR - https://www.scopus.com/pages/publications/85009743318
U2 - 10.1016/j.bjorl.2016.11.006
DO - 10.1016/j.bjorl.2016.11.006
M3 - Article
SN - 1808-8694
VL - 84
SP - 74
EP - 81
JO - Brazilian Journal of Otorhinolaryngology
JF - Brazilian Journal of Otorhinolaryngology
IS - 1
ER -
