Probiotics supplements reduce er stress and gut inflammation associated with gliadin intake in a mouse model of gluten sensitivity

Eleonora Ferrari, Romina Monzani, Valentina Saverio, Mara Gagliardi, Elżbieta Pańczyszyn, Valeria Raia, Valeria Rachela Villella, Gianni Bona, Marco Pane, Angela Amoruso, Marco Corazzari

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Exposure to gluten, a protein present in wheat rye and barley, is the major inducer for human Celiac Disease (CD), a chronic autoimmune enteropathy. CD occurs in about 1% worldwide population, in genetically predisposed individuals bearing human leukocyte antigen (HLA) DQ2/DQ8. Gut epithelial cell stress and the innate immune activation are responsible for the breaking oral tolerance to gliadin, a gluten component. To date, the only treatment available for CD is a long-term gluten-free diet. Several studies have shown that an altered composition of the intestinal microbiota (dysbiosis) could play a key role in the pathogenesis of CD through the modulation of intestinal permeability and the regulation of the immune system. Here, we show that gliadin induces a chronic endoplasmic reticulum (ER) stress condition in the small intestine of a gluten-sen-sitive mouse model and that the coadministration of probiotics efficiently attenuates both the (un-folded protein response (UPR) and gut inflammation. Moreover, the composition of probiotics for-mulations might differ in their activity at molecular level, especially toward the three axes of the UPR. Therefore, probiotics administration might potentially represent a new valuable strategy to treat gluten-sensitive patients, such as those affected by CD.

Lingua originaleInglese
Numero di articolo1221
RivistaNutrients
Volume13
Numero di pubblicazione4
DOI
Stato di pubblicazionePubblicato - apr 2021

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