TY - JOUR
T1 - Priming effects of mammalian tachykinins on human neutrophils
AU - Brunelleschi, Sandra
AU - Tarli, Sandra
AU - Giotti, Alberto
AU - Fantozzi, Roberto
N1 - Funding Information:
This work was supported in part by a MPI grant from the University of Ferrara.
PY - 1991
Y1 - 1991
N2 - The undecapeptide substance P (SP) is known to activate different cell types involved in inflammatory and immune processes. By evaluating primed stimulation of human neutrophils, we now demonstrate that SP (10 nM - 0.1 mM) dose-dependently enhances superoxide anion production from cells stimulated by the phospholipid mediator Platelet Activating Factor (PAF). We also provide evidence that neurokinin A (NKA), which is released, as well as SP, from C fibers of sensory nerves, potentiates PAF-evoked superoxide anion generation, while neurokinin B (NKB) is ineffective.
AB - The undecapeptide substance P (SP) is known to activate different cell types involved in inflammatory and immune processes. By evaluating primed stimulation of human neutrophils, we now demonstrate that SP (10 nM - 0.1 mM) dose-dependently enhances superoxide anion production from cells stimulated by the phospholipid mediator Platelet Activating Factor (PAF). We also provide evidence that neurokinin A (NKA), which is released, as well as SP, from C fibers of sensory nerves, potentiates PAF-evoked superoxide anion generation, while neurokinin B (NKB) is ineffective.
UR - http://www.scopus.com/inward/record.url?scp=0026025818&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(91)90416-9
DO - 10.1016/0024-3205(91)90416-9
M3 - Article
SN - 0024-3205
VL - 48
SP - PL1
JO - Life Sciences
JF - Life Sciences
IS - 2
ER -