Prevalence and clinical characteristics of immune thrombocytopenic purpura in a cohort of monoclonal gammopathy of uncertain significance

Davide ROSSI; Paoli L De; S Franceschetti; Daniela CAPELLO; C Vendramin; M Lunghi; A Conconi; Corrado MAGNANI; Gianluca GAIDANO

doi:10.1111/j.1365-2141.2007.06633.x

Prevalence and clinical characteristics of immune thrombocytopenic purpura in a cohort of monoclonal gammopathy of uncertain significance

Davide ROSSI, Paoli L De, S Franceschetti, Daniela CAPELLO, C Vendramin, M Lunghi, A Conconi, Corrado MAGNANI, Gianluca GAIDANO

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Monoclonal gammopathy of uncertain significance (MGUS) may become symptomatic for autoimmune manifestations. We report on the prevalence and clinical course of immune thrombocytopenic purpura (ITP) observed in a consecutive series of 228 MGUS patients. At MGUS diagnosis, ITP was determined in 6/228 cases, accounting for a prevalence of 2630/100 000 [95% confidence interval (CI): 1210-5620]. One incidental ITP case occurred after 21 months of follow-up. After a follow-up of 681.3 patient-years, the crude incidence of ITP in MGUS was 146.8 per 100 000 patient-year (95% CI: 3.7-817.8). Overall, these observations point to an association between MGUS and ITP.

Lingua originale	Inglese
pagine (da-a)	249-252
Numero di pagine	4
Rivista	British Journal of Haematology
Volume	138
Numero di pubblicazione	2
DOI	https://doi.org/10.1111/j.1365-2141.2007.06633.x
Stato di pubblicazione	Pubblicato - 2007

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10.1111/j.1365-2141.2007.06633.x

http://hdl.handle.net/11579/29422

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title = "Prevalence and clinical characteristics of immune thrombocytopenic purpura in a cohort of monoclonal gammopathy of uncertain significance",

abstract = "Monoclonal gammopathy of uncertain significance (MGUS) may become symptomatic for autoimmune manifestations. We report on the prevalence and clinical course of immune thrombocytopenic purpura (ITP) observed in a consecutive series of 228 MGUS patients. At MGUS diagnosis, ITP was determined in 6/228 cases, accounting for a prevalence of 2630/100 000 [95% confidence interval (CI): 1210-5620]. One incidental ITP case occurred after 21 months of follow-up. After a follow-up of 681.3 patient-years, the crude incidence of ITP in MGUS was 146.8 per 100 000 patient-year (95% CI: 3.7-817.8). Overall, these observations point to an association between MGUS and ITP.",

author = "Davide ROSSI and De, {Paoli L} and S Franceschetti and Daniela CAPELLO and C Vendramin and M Lunghi and A Conconi and Corrado MAGNANI and Gianluca GAIDANO",

year = "2007",

doi = "10.1111/j.1365-2141.2007.06633.x",

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T1 - Prevalence and clinical characteristics of immune thrombocytopenic purpura in a cohort of monoclonal gammopathy of uncertain significance

AU - ROSSI, Davide

AU - De, Paoli L

AU - Franceschetti, S

AU - CAPELLO, Daniela

AU - Vendramin, C

AU - Lunghi, M

AU - Conconi, A

AU - MAGNANI, Corrado

AU - GAIDANO, Gianluca

PY - 2007

Y1 - 2007

N2 - Monoclonal gammopathy of uncertain significance (MGUS) may become symptomatic for autoimmune manifestations. We report on the prevalence and clinical course of immune thrombocytopenic purpura (ITP) observed in a consecutive series of 228 MGUS patients. At MGUS diagnosis, ITP was determined in 6/228 cases, accounting for a prevalence of 2630/100 000 [95% confidence interval (CI): 1210-5620]. One incidental ITP case occurred after 21 months of follow-up. After a follow-up of 681.3 patient-years, the crude incidence of ITP in MGUS was 146.8 per 100 000 patient-year (95% CI: 3.7-817.8). Overall, these observations point to an association between MGUS and ITP.

AB - Monoclonal gammopathy of uncertain significance (MGUS) may become symptomatic for autoimmune manifestations. We report on the prevalence and clinical course of immune thrombocytopenic purpura (ITP) observed in a consecutive series of 228 MGUS patients. At MGUS diagnosis, ITP was determined in 6/228 cases, accounting for a prevalence of 2630/100 000 [95% confidence interval (CI): 1210-5620]. One incidental ITP case occurred after 21 months of follow-up. After a follow-up of 681.3 patient-years, the crude incidence of ITP in MGUS was 146.8 per 100 000 patient-year (95% CI: 3.7-817.8). Overall, these observations point to an association between MGUS and ITP.

UR - https://iris.uniupo.it/handle/11579/29422

U2 - 10.1111/j.1365-2141.2007.06633.x

DO - 10.1111/j.1365-2141.2007.06633.x

M3 - Article

SN - 0007-1048

VL - 138

SP - 249

EP - 252

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 2

ER -

Prevalence and clinical characteristics of immune thrombocytopenic purpura in a cohort of monoclonal gammopathy of uncertain significance

Abstract

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