Prevalence and characteristics of hpv infection in oropharyngeal cancer

Antonella De Stefani, Paolo Boffano, Gianluca Averono, Angela Ramella, Francesco Pia, Guido Bongioannini

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

BACKGROUND: The purpose of this prospective study was to analyze the human papillomavirus (HPV) infection status and its impact on the outcome in a consecutive series of patients affected by oropharyngeal cancer. METHODS: The specimens of consecutive subjects surgically treated for oropharyngeal squamous cell carcinoma were obtained. Samples were collected by broom-type cell sampling devices and they underwent the Roche Linear Array HPV Genotyping Test to identify the presence of HPV types. RESULTS: In all, 52 patients were enrolled. The presence of HPV was detected in 13 samples, with HPV type 16 as the most frequently encountered type. Statistically significant associations were found between HPV-positive patients and a higher tumor grading (P < 0.05), and between HPV-positive patients and a higher number of negative prognostic factors (P < 0.05). CONCLUSIONS: A subset of oropharyngeal squamous cell carcinomas with a higher tumor grading is strongly linked to HPV16 infection.
Lingua originaleInglese
pagine (da-a)e40-e43
RivistaJournal of Craniofacial Surgery
Volume24
Numero di pubblicazione1
DOI
Stato di pubblicazionePubblicato - gen 2013
Pubblicato esternamente

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