Abstract
BACKGROUND:
The purpose of this prospective study was to analyze the human papillomavirus (HPV) infection status and its impact on the outcome in a consecutive series of patients affected by oropharyngeal cancer.
METHODS:
The specimens of consecutive subjects surgically treated for oropharyngeal squamous cell carcinoma were obtained. Samples were collected by broom-type cell sampling devices and they underwent the Roche Linear Array HPV Genotyping Test to identify the presence of HPV types.
RESULTS:
In all, 52 patients were enrolled. The presence of HPV was detected in 13 samples, with HPV type 16 as the most frequently encountered type. Statistically significant associations were found between HPV-positive patients and a higher tumor grading (P < 0.05), and between HPV-positive patients and a higher number of negative prognostic factors (P < 0.05).
CONCLUSIONS:
A subset of oropharyngeal squamous cell carcinomas with a higher tumor grading is strongly linked to HPV16 infection.
Lingua originale | Inglese |
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pagine (da-a) | e40-e43 |
Rivista | Journal of Craniofacial Surgery |
Volume | 24 |
Numero di pubblicazione | 1 |
DOI | |
Stato di pubblicazione | Pubblicato - gen 2013 |
Pubblicato esternamente | Sì |