Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe

David J. Pinato; Alvin J.X. Lee; Federica Biello; Elia Seguí; Juan Aguilar-Company; Anna Carbó; Riccardo Bruna; Mark Bower; Gianpiero Rizzo; Sarah Benafif; Carme Carmona; Neha Chopra; Claudia Andrea Cruz; Francesca D’avanzo; Joanne S. Evans; Myria Galazi; Isabel Garcia-Fructuoso; Alessia Dalla Pria; Thomas Newsom-Davis; Diego Ottaviani; Andrea Patriarca; Roxana Reyes; Rachel Sharkey; Christopher C.T. Sng; Yien Ning Sophia Wong; Daniela Ferrante; Lorenza Scotti; Gian Carlo Avanzi; Mattia Bellan; Luigi Mario Castello; Javier Marco-Hernández; Meritxell Mollà; Mario Pirisi; Isabel Ruiz-Camps; Pier Paolo Sainaghi; Gianluca Gaidano; Joan Brunet; Josep Tabernero; Aleix Prat; Alessandra Gennari

doi:10.3390/cancers12071841

Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe

David J. Pinato, Alvin J.X. Lee, Federica Biello, Elia Seguí, Juan Aguilar-Company, Anna Carbó, Riccardo Bruna, Mark Bower, Gianpiero Rizzo, Sarah Benafif, Carme Carmona, Neha Chopra, Claudia Andrea Cruz, Francesca D’avanzo, Joanne S. Evans, Myria Galazi, Isabel Garcia-Fructuoso, Alessia Dalla Pria, Thomas Newsom-Davis, Diego OttavianiAndrea Patriarca, Roxana Reyes, Rachel Sharkey, Christopher C.T. Sng, Yien Ning Sophia Wong, Daniela Ferrante, Lorenza Scotti, Gian Carlo Avanzi, Mattia Bellan, Luigi Mario Castello, Javier Marco-Hernández, Meritxell Mollà, Mario Pirisi, Isabel Ruiz-Camps, Pier Paolo Sainaghi, Gianluca Gaidano, Joan Brunet, Josep Tabernero, Aleix Prat, Alessandra Gennari

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

We describe the outcomes in cancer patients during the initial outbreak of the COVID-19 in Europe from the retrospective, multi-center observational OnCovid study. We identified 204 cancer patients from eight centers in the United Kingdom, Italy, and Spain aged > 18 (mean = 69) and diagnosed with COVID-19 between February 26th and April 1st, 2020. A total of 127 (62%) were male, 184 (91%) had a diagnosis of solid malignancy, and 103 (51%) had non-metastatic disease. A total of 161 (79%) had > 1 co-morbidity. A total of 141 (69%) patients had > 1 COVID-19 complication. A total of 36 (19%) were escalated to high-dependency or intensive care. A total of 59 (29%) died, 53 (26%) were discharged, and 92 (45%) were in-hospital survivors. Mortality was higher in patients aged > 65 (36% versus 16%), in those with > 2 co-morbidities (40% versus 18%) and developing > 1 complication from COVID-19 (38% versus 4%, p = 0.004). Multi-variable analyses confirmed age > 65 and > 2 co-morbidities to predict for patient mortality independent of tumor stage, active malignancy, or anticancer therapy. During the early outbreak of SARS-CoV-2 infection in Europe co-morbid burden and advancing age predicted for adverse disease course in cancer patients. The ongoing OnCovid study will allow us to compare risks and outcomes in cancer patients between the initial and later stages of the COVID-19 pandemic.

Lingua originale	Inglese
Numero di articolo	1841
pagine (da-a)	1-13
Numero di pagine	13
Rivista	Cancers
Volume	12
Numero di pubblicazione	7
DOI	https://doi.org/10.3390/cancers12071841
Stato di pubblicazione	Pubblicato - lug 2020

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Pinato, D. J., Lee, A. J. X., Biello, F., Seguí, E., Aguilar-Company, J., Carbó, A., Bruna, R., Bower, M., Rizzo, G., Benafif, S., Carmona, C., Chopra, N., Cruz, C. A., D’avanzo, F., Evans, J. S., Galazi, M., Garcia-Fructuoso, I., Pria, A. D., Newsom-Davis, T., ... Gennari, A. (2020). Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe. Cancers, 12(7), 1-13. Articolo 1841. https://doi.org/10.3390/cancers12071841

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title = "Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe",

abstract = "We describe the outcomes in cancer patients during the initial outbreak of the COVID-19 in Europe from the retrospective, multi-center observational OnCovid study. We identified 204 cancer patients from eight centers in the United Kingdom, Italy, and Spain aged > 18 (mean = 69) and diagnosed with COVID-19 between February 26th and April 1st, 2020. A total of 127 (62%) were male, 184 (91%) had a diagnosis of solid malignancy, and 103 (51%) had non-metastatic disease. A total of 161 (79%) had > 1 co-morbidity. A total of 141 (69%) patients had > 1 COVID-19 complication. A total of 36 (19%) were escalated to high-dependency or intensive care. A total of 59 (29%) died, 53 (26%) were discharged, and 92 (45%) were in-hospital survivors. Mortality was higher in patients aged > 65 (36% versus 16%), in those with > 2 co-morbidities (40% versus 18%) and developing > 1 complication from COVID-19 (38% versus 4%, p = 0.004). Multi-variable analyses confirmed age > 65 and > 2 co-morbidities to predict for patient mortality independent of tumor stage, active malignancy, or anticancer therapy. During the early outbreak of SARS-CoV-2 infection in Europe co-morbid burden and advancing age predicted for adverse disease course in cancer patients. The ongoing OnCovid study will allow us to compare risks and outcomes in cancer patients between the initial and later stages of the COVID-19 pandemic.",

keywords = "COVID-19, Cancer, Coronavirus, Mortality, Outcomes, SARS-CoV-2, Survival",

author = "Pinato, {David J.} and Lee, {Alvin J.X.} and Federica Biello and Elia Segu{\'i} and Juan Aguilar-Company and Anna Carb{\'o} and Riccardo Bruna and Mark Bower and Gianpiero Rizzo and Sarah Benafif and Carme Carmona and Neha Chopra and Cruz, {Claudia Andrea} and Francesca D{\textquoteright}avanzo and Evans, {Joanne S.} and Myria Galazi and Isabel Garcia-Fructuoso and Pria, {Alessia Dalla} and Thomas Newsom-Davis and Diego Ottaviani and Andrea Patriarca and Roxana Reyes and Rachel Sharkey and Sng, {Christopher C.T.} and Wong, {Yien Ning Sophia} and Daniela Ferrante and Lorenza Scotti and Avanzi, {Gian Carlo} and Mattia Bellan and Castello, {Luigi Mario} and Javier Marco-Hern{\'a}ndez and Meritxell Moll{\`a} and Mario Pirisi and Isabel Ruiz-Camps and Sainaghi, {Pier Paolo} and Gianluca Gaidano and Joan Brunet and Josep Tabernero and Aleix Prat and Alessandra Gennari",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = jul,

doi = "10.3390/cancers12071841",

language = "English",

volume = "12",

pages = "1--13",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "7",

}

Pinato, DJ, Lee, AJX, Biello, F, Seguí, E, Aguilar-Company, J, Carbó, A, Bruna, R, Bower, M, Rizzo, G, Benafif, S, Carmona, C, Chopra, N, Cruz, CA, D’avanzo, F, Evans, JS, Galazi, M, Garcia-Fructuoso, I, Pria, AD, Newsom-Davis, T, Ottaviani, D, Patriarca, A, Reyes, R, Sharkey, R, Sng, CCT, Wong, YNS, Ferrante, D , Scotti, L, Avanzi, GC, Bellan, M , Castello, LM, Marco-Hernández, J, Mollà, M, Pirisi, M, Ruiz-Camps, I, Sainaghi, PP , Gaidano, G, Brunet, J, Tabernero, J, Prat, A & Gennari, A 2020, 'Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe', Cancers, vol. 12, n. 7, 1841, pagg. 1-13. https://doi.org/10.3390/cancers12071841

TY - JOUR

T1 - Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe

AU - Pinato, David J.

AU - Lee, Alvin J.X.

AU - Biello, Federica

AU - Seguí, Elia

AU - Aguilar-Company, Juan

AU - Carbó, Anna

AU - Bruna, Riccardo

AU - Bower, Mark

AU - Rizzo, Gianpiero

AU - Benafif, Sarah

AU - Carmona, Carme

AU - Chopra, Neha

AU - Cruz, Claudia Andrea

AU - D’avanzo, Francesca

AU - Evans, Joanne S.

AU - Galazi, Myria

AU - Garcia-Fructuoso, Isabel

AU - Pria, Alessia Dalla

AU - Newsom-Davis, Thomas

AU - Ottaviani, Diego

AU - Patriarca, Andrea

AU - Reyes, Roxana

AU - Sharkey, Rachel

AU - Sng, Christopher C.T.

AU - Wong, Yien Ning Sophia

AU - Ferrante, Daniela

AU - Scotti, Lorenza

AU - Avanzi, Gian Carlo

AU - Bellan, Mattia

AU - Castello, Luigi Mario

AU - Marco-Hernández, Javier

AU - Mollà, Meritxell

AU - Pirisi, Mario

AU - Ruiz-Camps, Isabel

AU - Sainaghi, Pier Paolo

AU - Gaidano, Gianluca

AU - Brunet, Joan

AU - Tabernero, Josep

AU - Prat, Aleix

AU - Gennari, Alessandra

PY - 2020/7

Y1 - 2020/7

N2 - We describe the outcomes in cancer patients during the initial outbreak of the COVID-19 in Europe from the retrospective, multi-center observational OnCovid study. We identified 204 cancer patients from eight centers in the United Kingdom, Italy, and Spain aged > 18 (mean = 69) and diagnosed with COVID-19 between February 26th and April 1st, 2020. A total of 127 (62%) were male, 184 (91%) had a diagnosis of solid malignancy, and 103 (51%) had non-metastatic disease. A total of 161 (79%) had > 1 co-morbidity. A total of 141 (69%) patients had > 1 COVID-19 complication. A total of 36 (19%) were escalated to high-dependency or intensive care. A total of 59 (29%) died, 53 (26%) were discharged, and 92 (45%) were in-hospital survivors. Mortality was higher in patients aged > 65 (36% versus 16%), in those with > 2 co-morbidities (40% versus 18%) and developing > 1 complication from COVID-19 (38% versus 4%, p = 0.004). Multi-variable analyses confirmed age > 65 and > 2 co-morbidities to predict for patient mortality independent of tumor stage, active malignancy, or anticancer therapy. During the early outbreak of SARS-CoV-2 infection in Europe co-morbid burden and advancing age predicted for adverse disease course in cancer patients. The ongoing OnCovid study will allow us to compare risks and outcomes in cancer patients between the initial and later stages of the COVID-19 pandemic.

AB - We describe the outcomes in cancer patients during the initial outbreak of the COVID-19 in Europe from the retrospective, multi-center observational OnCovid study. We identified 204 cancer patients from eight centers in the United Kingdom, Italy, and Spain aged > 18 (mean = 69) and diagnosed with COVID-19 between February 26th and April 1st, 2020. A total of 127 (62%) were male, 184 (91%) had a diagnosis of solid malignancy, and 103 (51%) had non-metastatic disease. A total of 161 (79%) had > 1 co-morbidity. A total of 141 (69%) patients had > 1 COVID-19 complication. A total of 36 (19%) were escalated to high-dependency or intensive care. A total of 59 (29%) died, 53 (26%) were discharged, and 92 (45%) were in-hospital survivors. Mortality was higher in patients aged > 65 (36% versus 16%), in those with > 2 co-morbidities (40% versus 18%) and developing > 1 complication from COVID-19 (38% versus 4%, p = 0.004). Multi-variable analyses confirmed age > 65 and > 2 co-morbidities to predict for patient mortality independent of tumor stage, active malignancy, or anticancer therapy. During the early outbreak of SARS-CoV-2 infection in Europe co-morbid burden and advancing age predicted for adverse disease course in cancer patients. The ongoing OnCovid study will allow us to compare risks and outcomes in cancer patients between the initial and later stages of the COVID-19 pandemic.

KW - COVID-19

KW - Cancer

KW - Coronavirus

KW - Mortality

KW - Outcomes

KW - SARS-CoV-2

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=85087774791&partnerID=8YFLogxK

U2 - 10.3390/cancers12071841

DO - 10.3390/cancers12071841

M3 - Article

SN - 2072-6694

VL - 12

SP - 1

EP - 13

JO - Cancers

JF - Cancers

IS - 7

M1 - 1841

ER -

Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe

Abstract

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