TY - JOUR
T1 - Pregnancy and Renal Transplantation
T2 - A Case Report of the Risk of Antibody Induction Against Partner Antigens
AU - Cornella, C.
AU - Riboni, F.
AU - Praticò, L.
AU - Conca, R.
AU - Fenoglio, R.
AU - Lazzarich, E.
AU - Surico, N.
AU - Paternoster, D. M.
PY - 2009/11
Y1 - 2009/11
N2 - Renal transplantation has provided women of childbearing age with increased fertility and the possibility of successful pregnancy outcomes. Approximately 14,000 births among women with transplanted organs have been reported worldwide, but pregnancy complications have been frequent: spontaneous or therapeutic abortion, preterm birth, low birth weight, and intrauterine growth restriction. Herein we have described a case of an acute rejection episode in a renal transplant recipient, occurring 6 months after successful delivery, despite the fulfillment of all European best practice guidelines criteria and the maintenance of adequate immunosuppression. Our case demonstrated that even a presumably low-risk patient can face worsening of renal function during or after pregnancy. Acute immune activation is uncommon but may occur in late-onset fashion. Despite adequate levels of maintenance immunosuppression, there is a risk of developing antibodies against the partner or the donor, causing acute renal immune damage.
AB - Renal transplantation has provided women of childbearing age with increased fertility and the possibility of successful pregnancy outcomes. Approximately 14,000 births among women with transplanted organs have been reported worldwide, but pregnancy complications have been frequent: spontaneous or therapeutic abortion, preterm birth, low birth weight, and intrauterine growth restriction. Herein we have described a case of an acute rejection episode in a renal transplant recipient, occurring 6 months after successful delivery, despite the fulfillment of all European best practice guidelines criteria and the maintenance of adequate immunosuppression. Our case demonstrated that even a presumably low-risk patient can face worsening of renal function during or after pregnancy. Acute immune activation is uncommon but may occur in late-onset fashion. Despite adequate levels of maintenance immunosuppression, there is a risk of developing antibodies against the partner or the donor, causing acute renal immune damage.
UR - http://www.scopus.com/inward/record.url?scp=71749083363&partnerID=8YFLogxK
U2 - 10.1016/j.transproceed.2009.06.233
DO - 10.1016/j.transproceed.2009.06.233
M3 - Article
SN - 0041-1345
VL - 41
SP - 3964
EP - 3966
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 9
ER -