Predictors of Mortality in Patients with COVID-19 Infection in Different Health- Care Settings: A Retrospective Analysis from a CORACLE Study Group

Lucio BOGLIONE, Silvia Corcione, Nour Shbaklo, Tommaso Lupia, Silvia Scabini, Simone Mornese Pinna, Silvio Borrè, Francesco Giuseppe De Rosa

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Background: Despite the large number of hospitalized patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, few data are available about risk factors and mortality in subjects with nosocomially acquired respiratory infection of Coronavirus Disease 2019 (COVID-19). Methods: We retrospectively evaluated in a multicentric study -during the pre-vaccination era-all patients admitted with confirmed diagnosis of nosocomial COVID-19 (NC). Patients were classified according to provenance: hospital-acquired NC or long-term care (LTC) facilities. Results: Among overall 1047 patients evaluated with COVID-19, 137 had a confirmed diagnosis of NC (13%). 78 (56.9%) patients had hospital-acquired NC and 59 (43%) had LTC NC. Overall mortality was 35.8%, in hospital-acquired NC 24.4%, in LTC NC 50.8% (p < 0.001) (Log Rank test: p = 0.001). Timing of diagnosis was significantly different between hospital acquired and LTC NC (3.5 vs 10 days, p < 0.001). In multivariate analysis age, intensive-care unit admission, LTC provenance and sepsis were significant predictors of mortality in patients with NC infection. Conclusion: Patients with NC are at higher risk of mortality (especially for LTC NC) and required preventive strategies, early diagnosis, and treatment to avoid COVID-19 cluster.

Lingua originaleInglese
RivistaINFECTION, DISEASE & HEALTH
DOI
Stato di pubblicazionePubblicato - 2022

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