Predictive markers of pre-eclampsia in hypertensive disorders of pregnancy

D. M. Paternoster, A. Stella, M. Mussap, M. Plebani, G. Gambaro, P. V. Grella

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Objective: The aim of this work is to assess the most widespread methods currently proposed and two new markers for predicting the development of pre-eclampsia in pregnant women with hypertension. Methods: The study involved 212 pregnant Caucasian women: 104 normotensive, 68 pregnancy-induced hypertensive and 40 chronic hypertensive. Blood and urine were sampled between 28 and 30 weeks gestation. All 108 hypertensive pregnant women, at the time of sampling, demonstrated proteinuria below 0.3 g/24 h. The following laboratory tests were performed: fibronectin, antithrombin-III, α-1-microglobulin, U-N-acetyl-β-glucosaminidase, uric acid and albumin excretion rate. Student's t-test, discriminant analysis and χ2 (chi-square) test were used as statistical methods. A P value less than 0.05 was considered significant. Results: After discriminating analysis, only three of the six variables analyzed were able to discriminate patients who would develop pre-eclampsia from the remaining hypertensive pregnant women: microalbuminuria, uric acid and fibronectin (χ2=29.122, P<0.01). Conclusions: In agreement with previous studies, albumin excretion rate appeared to be the best predictive test for pre-eclampsia in hypertensive pregnant women, giving a higher positive predictive value and specificity (87.5 and 98.9%, respectively). Copyright (C) 1999 International Federation of Gynecology and Obstetrics.

Lingua originaleInglese
pagine (da-a)237-243
Numero di pagine7
RivistaInternational Journal of Gynecology and Obstetrics
Volume66
Numero di pubblicazione3
DOI
Stato di pubblicazionePubblicato - 1 set 1999
Pubblicato esternamente

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