Prediagnostic Plasma Bile Acid Levels and Colon Cancer Risk: A Prospective Study

T. Kuhn; M. Stepien; M. Lopez-Nogueroles; A. Damms-Machado; D. Sookthai; T. Johnson; M. Roca; A. Husing; S. G. Maldonado; A. J. Cross; N. Murphy; H. Freisling; S. Rinaldi; A. Scalbert; V. Fedirko; G. Severi; Boutron-Ruault M. -C.; F. R. Mancini; S. A. Sowah; H. Boeing; P. Jakszyn; M. J. Sanchez; S. Merino; S. Colorado-Yohar; A. Barricarte; K. T. Khaw; J. A. Schmidt; A. Perez-Cornago; A. Trichopoulou; A. Karakatsani; P. Thriskos; D. Palli; C. Agnoli; R. Tumino; Carlotta SACERDOTE; S. Panico; B. Bueno-De-Mesquita; Gils C. H. Van; A. K. Heath; M. J. Gunter; E. Riboli; A. Lahoz; M. Jenab; R. Kaaks

doi:10.1093/jnci/djz166

Prediagnostic Plasma Bile Acid Levels and Colon Cancer Risk: A Prospective Study

T. Kuhn, M. Stepien, M. Lopez-Nogueroles, A. Damms-Machado, D. Sookthai, T. Johnson, M. Roca, A. Husing, S. G. Maldonado, A. J. Cross, N. Murphy, H. Freisling, S. Rinaldi, A. Scalbert, V. Fedirko, G. Severi, Boutron-Ruault M. -C., F. R. Mancini, S. A. Sowah, H. BoeingP. Jakszyn, M. J. Sanchez, S. Merino, S. Colorado-Yohar, A. Barricarte, K. T. Khaw, J. A. Schmidt, A. Perez-Cornago, A. Trichopoulou, A. Karakatsani, P. Thriskos, D. Palli, C. Agnoli, R. Tumino, Carlotta SACERDOTE, S. Panico, B. Bueno-De-Mesquita, Gils C. H. Van, A. K. Heath, M. J. Gunter, E. Riboli, A. Lahoz, M. Jenab, R. Kaaks

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Background: Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and colon cancer risk in humans. Methods: Associations between prediagnostic plasma levels of 17 primary, secondary, and tertiary bile acid metabolites (conjugated and unconjugated) and colon cancer risk were evaluated in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Bile acid levels were quantified by tandem mass spectrometry in samples from 569 incident colon cancer cases and 569 matched controls. Multivariable logistic regression analyses were used to estimate odds ratios (ORs) for colon cancer risk across quartiles of bile acid concentrations. Results: Positive associations were observed between colon cancer risk and plasma levels of seven conjugated bile acid metabolites: the primary bile acids glycocholic acid (ORquartile 4 vs quartile 1= 2.22, 95% confidence interval [CI] = 1.52 to 3.26), taurocholic acid (OR = 1.78, 95% CI = 1.23 to 2.58), glycochenodeoxycholic acid (OR = 1.68, 95% CI = 1.13 to 2.48), taurochenodeoxycholic acid (OR = 1.62, 95% CI = 1.11 to 2.36), and glycohyocholic acid (OR = 1.65, 95% CI = 1.13 to 2.40), and the secondary bile acids glycodeoxycholic acid (OR = 1.68, 95% CI = 1.12 to 2.54) and taurodeoxycholic acid (OR = 1.54, 95% CI = 1.02 to 2.31). By contrast, unconjugated bile acids and tertiary bile acids were not associated with risk. Conclusions: This prospective study showed that prediagnostic levels of certain conjugated primary and secondary bile acids were positively associated with risk of colon cancer. Our findings support experimental data to suggest that a high bile acid load is colon cancer promotive.

Lingua originale	Inglese
pagine (da-a)	516-524
Numero di pagine	9
Rivista	Journal of the National Cancer Institute
Volume	112
Numero di pubblicazione	5
DOI	https://doi.org/10.1093/jnci/djz166
Stato di pubblicazione	Pubblicato - 2020

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10.1093/jnci/djz166

https://hdl.handle.net/11579/198302

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Kuhn, T., Stepien, M., Lopez-Nogueroles, M., Damms-Machado, A., Sookthai, D., Johnson, T., Roca, M., Husing, A., Maldonado, S. G., Cross, A. J., Murphy, N., Freisling, H., Rinaldi, S., Scalbert, A., Fedirko, V., Severi, G., -C., B.-R. M., Mancini, F. R., Sowah, S. A., ... Kaaks, R. (2020). Prediagnostic Plasma Bile Acid Levels and Colon Cancer Risk: A Prospective Study. Journal of the National Cancer Institute, 112(5), 516-524. https://doi.org/10.1093/jnci/djz166

@article{7118cb88afe2482698183ea56067e2b9,

title = "Prediagnostic Plasma Bile Acid Levels and Colon Cancer Risk: A Prospective Study",

abstract = "Background: Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and colon cancer risk in humans. Methods: Associations between prediagnostic plasma levels of 17 primary, secondary, and tertiary bile acid metabolites (conjugated and unconjugated) and colon cancer risk were evaluated in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Bile acid levels were quantified by tandem mass spectrometry in samples from 569 incident colon cancer cases and 569 matched controls. Multivariable logistic regression analyses were used to estimate odds ratios (ORs) for colon cancer risk across quartiles of bile acid concentrations. Results: Positive associations were observed between colon cancer risk and plasma levels of seven conjugated bile acid metabolites: the primary bile acids glycocholic acid (ORquartile 4 vs quartile 1= 2.22, 95% confidence interval [CI] = 1.52 to 3.26), taurocholic acid (OR = 1.78, 95% CI = 1.23 to 2.58), glycochenodeoxycholic acid (OR = 1.68, 95% CI = 1.13 to 2.48), taurochenodeoxycholic acid (OR = 1.62, 95% CI = 1.11 to 2.36), and glycohyocholic acid (OR = 1.65, 95% CI = 1.13 to 2.40), and the secondary bile acids glycodeoxycholic acid (OR = 1.68, 95% CI = 1.12 to 2.54) and taurodeoxycholic acid (OR = 1.54, 95% CI = 1.02 to 2.31). By contrast, unconjugated bile acids and tertiary bile acids were not associated with risk. Conclusions: This prospective study showed that prediagnostic levels of certain conjugated primary and secondary bile acids were positively associated with risk of colon cancer. Our findings support experimental data to suggest that a high bile acid load is colon cancer promotive.",

author = "T. Kuhn and M. Stepien and M. Lopez-Nogueroles and A. Damms-Machado and D. Sookthai and T. Johnson and M. Roca and A. Husing and Maldonado, {S. G.} and Cross, {A. J.} and N. Murphy and H. Freisling and S. Rinaldi and A. Scalbert and V. Fedirko and G. Severi and -C., {Boutron-Ruault M.} and Mancini, {F. R.} and Sowah, {S. A.} and H. Boeing and P. Jakszyn and Sanchez, {M. J.} and S. Merino and S. Colorado-Yohar and A. Barricarte and Khaw, {K. T.} and Schmidt, {J. A.} and A. Perez-Cornago and A. Trichopoulou and A. Karakatsani and P. Thriskos and D. Palli and C. Agnoli and R. Tumino and Carlotta SACERDOTE and S. Panico and B. Bueno-De-Mesquita and Van, {Gils C. H.} and Heath, {A. K.} and Gunter, {M. J.} and E. Riboli and A. Lahoz and M. Jenab and R. Kaaks",

year = "2020",

doi = "10.1093/jnci/djz166",

language = "English",

volume = "112",

pages = "516--524",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "5",

}

Kuhn, T, Stepien, M, Lopez-Nogueroles, M, Damms-Machado, A, Sookthai, D, Johnson, T, Roca, M, Husing, A, Maldonado, SG, Cross, AJ, Murphy, N, Freisling, H, Rinaldi, S, Scalbert, A, Fedirko, V, Severi, G, -C., B-RM, Mancini, FR, Sowah, SA, Boeing, H, Jakszyn, P, Sanchez, MJ, Merino, S, Colorado-Yohar, S, Barricarte, A, Khaw, KT, Schmidt, JA, Perez-Cornago, A, Trichopoulou, A, Karakatsani, A, Thriskos, P, Palli, D, Agnoli, C, Tumino, R, SACERDOTE, C, Panico, S, Bueno-De-Mesquita, B, Van, GCH, Heath, AK, Gunter, MJ, Riboli, E, Lahoz, A, Jenab, M & Kaaks, R 2020, 'Prediagnostic Plasma Bile Acid Levels and Colon Cancer Risk: A Prospective Study', Journal of the National Cancer Institute, vol. 112, n. 5, pagg. 516-524. https://doi.org/10.1093/jnci/djz166

TY - JOUR

T1 - Prediagnostic Plasma Bile Acid Levels and Colon Cancer Risk: A Prospective Study

AU - Kuhn, T.

AU - Stepien, M.

AU - Lopez-Nogueroles, M.

AU - Damms-Machado, A.

AU - Sookthai, D.

AU - Johnson, T.

AU - Roca, M.

AU - Husing, A.

AU - Maldonado, S. G.

AU - Cross, A. J.

AU - Murphy, N.

AU - Freisling, H.

AU - Rinaldi, S.

AU - Scalbert, A.

AU - Fedirko, V.

AU - Severi, G.

AU - -C., Boutron-Ruault M.

AU - Mancini, F. R.

AU - Sowah, S. A.

AU - Boeing, H.

AU - Jakszyn, P.

AU - Sanchez, M. J.

AU - Merino, S.

AU - Colorado-Yohar, S.

AU - Barricarte, A.

AU - Khaw, K. T.

AU - Schmidt, J. A.

AU - Perez-Cornago, A.

AU - Trichopoulou, A.

AU - Karakatsani, A.

AU - Thriskos, P.

AU - Palli, D.

AU - Agnoli, C.

AU - Tumino, R.

AU - SACERDOTE, Carlotta

AU - Panico, S.

AU - Bueno-De-Mesquita, B.

AU - Van, Gils C. H.

AU - Heath, A. K.

AU - Gunter, M. J.

AU - Riboli, E.

AU - Lahoz, A.

AU - Jenab, M.

AU - Kaaks, R.

PY - 2020

Y1 - 2020

N2 - Background: Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and colon cancer risk in humans. Methods: Associations between prediagnostic plasma levels of 17 primary, secondary, and tertiary bile acid metabolites (conjugated and unconjugated) and colon cancer risk were evaluated in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Bile acid levels were quantified by tandem mass spectrometry in samples from 569 incident colon cancer cases and 569 matched controls. Multivariable logistic regression analyses were used to estimate odds ratios (ORs) for colon cancer risk across quartiles of bile acid concentrations. Results: Positive associations were observed between colon cancer risk and plasma levels of seven conjugated bile acid metabolites: the primary bile acids glycocholic acid (ORquartile 4 vs quartile 1= 2.22, 95% confidence interval [CI] = 1.52 to 3.26), taurocholic acid (OR = 1.78, 95% CI = 1.23 to 2.58), glycochenodeoxycholic acid (OR = 1.68, 95% CI = 1.13 to 2.48), taurochenodeoxycholic acid (OR = 1.62, 95% CI = 1.11 to 2.36), and glycohyocholic acid (OR = 1.65, 95% CI = 1.13 to 2.40), and the secondary bile acids glycodeoxycholic acid (OR = 1.68, 95% CI = 1.12 to 2.54) and taurodeoxycholic acid (OR = 1.54, 95% CI = 1.02 to 2.31). By contrast, unconjugated bile acids and tertiary bile acids were not associated with risk. Conclusions: This prospective study showed that prediagnostic levels of certain conjugated primary and secondary bile acids were positively associated with risk of colon cancer. Our findings support experimental data to suggest that a high bile acid load is colon cancer promotive.

AB - Background: Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and colon cancer risk in humans. Methods: Associations between prediagnostic plasma levels of 17 primary, secondary, and tertiary bile acid metabolites (conjugated and unconjugated) and colon cancer risk were evaluated in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Bile acid levels were quantified by tandem mass spectrometry in samples from 569 incident colon cancer cases and 569 matched controls. Multivariable logistic regression analyses were used to estimate odds ratios (ORs) for colon cancer risk across quartiles of bile acid concentrations. Results: Positive associations were observed between colon cancer risk and plasma levels of seven conjugated bile acid metabolites: the primary bile acids glycocholic acid (ORquartile 4 vs quartile 1= 2.22, 95% confidence interval [CI] = 1.52 to 3.26), taurocholic acid (OR = 1.78, 95% CI = 1.23 to 2.58), glycochenodeoxycholic acid (OR = 1.68, 95% CI = 1.13 to 2.48), taurochenodeoxycholic acid (OR = 1.62, 95% CI = 1.11 to 2.36), and glycohyocholic acid (OR = 1.65, 95% CI = 1.13 to 2.40), and the secondary bile acids glycodeoxycholic acid (OR = 1.68, 95% CI = 1.12 to 2.54) and taurodeoxycholic acid (OR = 1.54, 95% CI = 1.02 to 2.31). By contrast, unconjugated bile acids and tertiary bile acids were not associated with risk. Conclusions: This prospective study showed that prediagnostic levels of certain conjugated primary and secondary bile acids were positively associated with risk of colon cancer. Our findings support experimental data to suggest that a high bile acid load is colon cancer promotive.

UR - https://iris.uniupo.it/handle/11579/198302

U2 - 10.1093/jnci/djz166

DO - 10.1093/jnci/djz166

M3 - Article

SN - 0027-8874

VL - 112

SP - 516

EP - 524

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 5

ER -

Prediagnostic Plasma Bile Acid Levels and Colon Cancer Risk: A Prospective Study

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