Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer

G. Bogani; V. D. Donato; G. Scambia; F. Landoni; F. Ghezzi; L. Muzii; P. B. Panici; F. Raspagliesi; J. Casarin; Martino G. Di; T. Grassi; A. M. Perrone; Iaco P. De; F. Multinu; R. Berretta; V. A. Capozzi; E. Zupi; G. Centini; A. Pellegrino; S. Corso; G. Stevenazzi; A. C. Boschi; G. Comerci; P. Greco; G. Scutiero; F. Sopracordevole; G. Giorda; M. Fichera; T. Simoncini; M. Caretto; E. Sartori; F. Ferrari; A. Cianci; G. Sarpietro; M. G. Matarazzo; P. Giampaolino; G. Bifulco; M. Morelli; M. D. Dio; A. Ferrero; N. Biglia; F. Barra; S. Ferrero; S. Cianci; V. Chiantera; G. Sozzi; A. Ercoli; S. Schettini; T. Orlando; F. G. Cannone; G. Ettore; A. Puppo; E. Olearo; Roberti Maggiore U. Leone; V. Artuso; I. Palaia; G. Perniola; R. Tripodi; T. G. D'Auge; I. Cuccu; M. Fischetti; G. Santangelo; A. Casorelli; A. Giannini; O. D'Oria; G. Vizzielli; S. Restaino; A. Bergamini; L. Bocciolone; F. Plotti; R. Angioli; G. Mantovani; M. Ceccaroni; C. Cassini; M. Dominoni; L. Giambanco; S. Amodeo; L. Leo; R. Thommaset; D. Raimondo; R. Seracchioli; M. Malzoni; F. Falcone; F. Gorlero; Luca M. Di; E. Busato; S. Kilzie; A. Dell'Acqua; G. Scarfone; P. Vercellini; M. Petrillo; G. Capobianco; A. Ciavattini; L. Mereu; P. Scollo; F. Sorbi; M. Fambrini; F. Romano; G. Ricci; G. Trojano; G. R. Damiani; R. Consonni; Lorenzo N. Di; A. Lippolis; R. Tinelli; L. Aguzzoli; V. D. Mandato; S. Palomba; M. Tripodi; D. Calandra; F. Pellegrini; F. Zullo; Daniela SURICO; VALENTINO REMORGIDA; F. Ruscitto; P. Beretta; E. Vizza

doi:10.1016/j.ygyno.2022.07.022

Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer

G. Bogani
, V. D. Donato
, G. Scambia
, F. Landoni
, F. Ghezzi
, L. Muzii
, P. B. Panici
, F. Raspagliesi
, J. Casarin
, Martino G. Di
, T. Grassi
, A. M. Perrone
, Iaco P. De
, F. Multinu
, R. Berretta
, V. A. Capozzi
, E. Zupi
, G. Centini
, A. Pellegrino
, S. Corso

G. Stevenazzi, A. C. Boschi, G. Comerci, P. Greco, G. Scutiero, F. Sopracordevole, G. Giorda, M. Fichera, T. Simoncini, M. Caretto, E. Sartori, F. Ferrari, A. Cianci, G. Sarpietro, M. G. Matarazzo, P. Giampaolino, G. Bifulco, M. Morelli, M. D. Dio, A. Ferrero, N. Biglia, F. Barra, S. Ferrero, S. Cianci, V. Chiantera, G. Sozzi, A. Ercoli, S. Schettini, T. Orlando, F. G. Cannone, G. Ettore, A. Puppo, E. Olearo, Roberti Maggiore U. Leone, V. Artuso, I. Palaia, G. Perniola, R. Tripodi, T. G. D'Auge, I. Cuccu, M. Fischetti, G. Santangelo, A. Casorelli, A. Giannini, O. D'Oria, G. Vizzielli, S. Restaino, A. Bergamini, L. Bocciolone, F. Plotti, R. Angioli, G. Mantovani, M. Ceccaroni, C. Cassini, M. Dominoni, L. Giambanco, S. Amodeo, L. Leo, R. Thommaset, D. Raimondo, R. Seracchioli, M. Malzoni, F. Falcone, F. Gorlero, Luca M. Di, E. Busato, S. Kilzie, A. Dell'Acqua, G. Scarfone, P. Vercellini, M. Petrillo, G. Capobianco, A. Ciavattini, L. Mereu, P. Scollo, F. Sorbi, M. Fambrini, F. Romano, G. Ricci, G. Trojano, G. R. Damiani, R. Consonni, Lorenzo N. Di, A. Lippolis, R. Tinelli, L. Aguzzoli, V. D. Mandato, S. Palomba, M. Tripodi, D. Calandra, F. Pellegrini, F. Zullo, Daniela SURICO, VALENTINO REMORGIDA, F. Ruscitto, P. Beretta, E. Vizza

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Background: To evaluate the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial on patterns of care and surgery-related morbidity in early-stage cervical cancer. Methods: This is a retrospective, a multi-institutional study evaluating 90-day surgery-related outcomes of patients undergoing treatment for early-stage cervical cancer before (period I: 01/01/2016–06/01/2018) and after (period II: 01/01/2019–06/01/2021) the publication of the results of the LACC trial. Results: Charts of 1295 patients were evaluated: 581 (44.9%) and 714 (55.1%) before and after the publication of the LACC trial, respectively. After the publication of the LACC trial, the number of patients treated with minimally invasive radical hysterectomy decreased from 64.9% to 30.4% (p < 0.001). Overall, 90-day complications occurred in 110 (18.9%) and 119 (16.6%) patients in the period I and period II, respectively (p = 0.795). Similarly, the number of severe (grade 3 or worse) complications did not differ between the two periods (38 (6.5%) vs. 37 (5.1%); p = 0.297). Overall and severe 90-day complications were consistent between periods even evaluating stage IA (p = 0.471), IB1 (p = 0.929), and IB2 (p = 0.074), separately. Conclusions: The present investigation highlighted that in referral centers the shift from minimally invasive to open radical hysterectomy does not influence 90-day surgery-related morbidity.

Lingua originale	Inglese
pagine (da-a)	561-566
Numero di pagine	6
Rivista	Gynecologic Oncology
Volume	166
Numero di pubblicazione	3
DOI	https://doi.org/10.1016/j.ygyno.2022.07.022
Stato di pubblicazione	Pubblicato - 2022

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

SDG 3 Salute e benessere

Keywords

Complications
Laparoscopy
Morbidity
Radical hysterectomy

Accesso al documento

10.1016/j.ygyno.2022.07.022

https://hdl.handle.net/11579/155602

Altri file e collegamenti

handle

Cita questo

Bogani, G., Donato, V. D., Scambia, G., Landoni, F., Ghezzi, F., Muzii, L., Panici, P. B., Raspagliesi, F., Casarin, J., Di, M. G., Grassi, T., Perrone, A. M., De, I. P., Multinu, F., Berretta, R., Capozzi, V. A., Zupi, E., Centini, G., Pellegrino, A., ... Vizza, E. (2022). Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer. Gynecologic Oncology, 166(3), 561-566. https://doi.org/10.1016/j.ygyno.2022.07.022

@article{5493ebf0cf034abd87681ec9feb16047,

title = "Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer",

abstract = "Background: To evaluate the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial on patterns of care and surgery-related morbidity in early-stage cervical cancer. Methods: This is a retrospective, a multi-institutional study evaluating 90-day surgery-related outcomes of patients undergoing treatment for early-stage cervical cancer before (period I: 01/01/2016–06/01/2018) and after (period II: 01/01/2019–06/01/2021) the publication of the results of the LACC trial. Results: Charts of 1295 patients were evaluated: 581 (44.9\%) and 714 (55.1\%) before and after the publication of the LACC trial, respectively. After the publication of the LACC trial, the number of patients treated with minimally invasive radical hysterectomy decreased from 64.9\% to 30.4\% (p < 0.001). Overall, 90-day complications occurred in 110 (18.9\%) and 119 (16.6\%) patients in the period I and period II, respectively (p = 0.795). Similarly, the number of severe (grade 3 or worse) complications did not differ between the two periods (38 (6.5\%) vs. 37 (5.1\%); p = 0.297). Overall and severe 90-day complications were consistent between periods even evaluating stage IA (p = 0.471), IB1 (p = 0.929), and IB2 (p = 0.074), separately. Conclusions: The present investigation highlighted that in referral centers the shift from minimally invasive to open radical hysterectomy does not influence 90-day surgery-related morbidity.",

keywords = "Complications, Laparoscopy, Morbidity, Radical hysterectomy, Complications, Laparoscopy, Morbidity, Radical hysterectomy",

author = "G. Bogani and Donato, \{V. D.\} and G. Scambia and F. Landoni and F. Ghezzi and L. Muzii and Panici, \{P. B.\} and F. Raspagliesi and J. Casarin and Di, \{Martino G.\} and T. Grassi and Perrone, \{A. M.\} and De, \{Iaco P.\} and F. Multinu and R. Berretta and Capozzi, \{V. A.\} and E. Zupi and G. Centini and A. Pellegrino and S. Corso and G. Stevenazzi and Boschi, \{A. C.\} and G. Comerci and P. Greco and G. Scutiero and F. Sopracordevole and G. Giorda and M. Fichera and T. Simoncini and M. Caretto and E. Sartori and F. Ferrari and A. Cianci and G. Sarpietro and Matarazzo, \{M. G.\} and P. Giampaolino and G. Bifulco and M. Morelli and Dio, \{M. D.\} and A. Ferrero and N. Biglia and F. Barra and S. Ferrero and S. Cianci and V. Chiantera and G. Sozzi and A. Ercoli and S. Schettini and T. Orlando and Cannone, \{F. G.\} and G. Ettore and A. Puppo and E. Olearo and Leone, \{Roberti Maggiore U.\} and V. Artuso and I. Palaia and G. Perniola and R. Tripodi and D'Auge, \{T. G.\} and I. Cuccu and M. Fischetti and G. Santangelo and A. Casorelli and A. Giannini and O. D'Oria and G. Vizzielli and S. Restaino and A. Bergamini and L. Bocciolone and F. Plotti and R. Angioli and G. Mantovani and M. Ceccaroni and C. Cassini and M. Dominoni and L. Giambanco and S. Amodeo and L. Leo and R. Thommaset and D. Raimondo and R. Seracchioli and M. Malzoni and F. Falcone and F. Gorlero and Di, \{Luca M.\} and E. Busato and S. Kilzie and A. Dell'Acqua and G. Scarfone and P. Vercellini and M. Petrillo and G. Capobianco and A. Ciavattini and L. Mereu and P. Scollo and F. Sorbi and M. Fambrini and F. Romano and G. Ricci and G. Trojano and Damiani, \{G. R.\} and R. Consonni and Di, \{Lorenzo N.\} and A. Lippolis and R. Tinelli and L. Aguzzoli and Mandato, \{V. D.\} and S. Palomba and M. Tripodi and D. Calandra and F. Pellegrini and F. Zullo and Daniela SURICO and VALENTINO REMORGIDA and F. Ruscitto and P. Beretta and E. Vizza",

year = "2022",

doi = "10.1016/j.ygyno.2022.07.022",

language = "English",

volume = "166",

pages = "561--566",

journal = "Gynecologic Oncology",

issn = "0090-8258",

publisher = "Academic Press Inc.",

number = "3",

}

Bogani, G, Donato, VD, Scambia, G, Landoni, F, Ghezzi, F, Muzii, L, Panici, PB, Raspagliesi, F, Casarin, J, Di, MG, Grassi, T, Perrone, AM, De, IP, Multinu, F, Berretta, R, Capozzi, VA, Zupi, E, Centini, G, Pellegrino, A, Corso, S, Stevenazzi, G, Boschi, AC, Comerci, G, Greco, P, Scutiero, G, Sopracordevole, F, Giorda, G, Fichera, M, Simoncini, T, Caretto, M, Sartori, E, Ferrari, F, Cianci, A, Sarpietro, G, Matarazzo, MG, Giampaolino, P, Bifulco, G, Morelli, M, Dio, MD, Ferrero, A, Biglia, N, Barra, F, Ferrero, S, Cianci, S, Chiantera, V, Sozzi, G, Ercoli, A, Schettini, S, Orlando, T, Cannone, FG, Ettore, G, Puppo, A, Olearo, E, Leone, RMU, Artuso, V, Palaia, I, Perniola, G, Tripodi, R, D'Auge, TG, Cuccu, I, Fischetti, M, Santangelo, G, Casorelli, A, Giannini, A, D'Oria, O, Vizzielli, G, Restaino, S, Bergamini, A, Bocciolone, L, Plotti, F, Angioli, R, Mantovani, G, Ceccaroni, M, Cassini, C, Dominoni, M, Giambanco, L, Amodeo, S, Leo, L, Thommaset, R, Raimondo, D, Seracchioli, R, Malzoni, M, Falcone, F, Gorlero, F, Di, LM, Busato, E, Kilzie, S, Dell'Acqua, A, Scarfone, G, Vercellini, P, Petrillo, M, Capobianco, G, Ciavattini, A, Mereu, L, Scollo, P, Sorbi, F, Fambrini, M, Romano, F, Ricci, G, Trojano, G, Damiani, GR, Consonni, R, Di, LN, Lippolis, A, Tinelli, R, Aguzzoli, L, Mandato, VD, Palomba, S, Tripodi, M, Calandra, D, Pellegrini, F, Zullo, F, SURICO, D , REMORGIDA, VALENTINO, Ruscitto, F, Beretta, P & Vizza, E 2022, 'Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer', Gynecologic Oncology, vol. 166, n. 3, pagg. 561-566. https://doi.org/10.1016/j.ygyno.2022.07.022

TY - JOUR

T1 - Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer

AU - Bogani, G.

AU - Donato, V. D.

AU - Scambia, G.

AU - Landoni, F.

AU - Ghezzi, F.

AU - Muzii, L.

AU - Panici, P. B.

AU - Raspagliesi, F.

AU - Casarin, J.

AU - Di, Martino G.

AU - Grassi, T.

AU - Perrone, A. M.

AU - De, Iaco P.

AU - Multinu, F.

AU - Berretta, R.

AU - Capozzi, V. A.

AU - Zupi, E.

AU - Centini, G.

AU - Pellegrino, A.

AU - Corso, S.

AU - Stevenazzi, G.

AU - Boschi, A. C.

AU - Comerci, G.

AU - Greco, P.

AU - Scutiero, G.

AU - Sopracordevole, F.

AU - Giorda, G.

AU - Fichera, M.

AU - Simoncini, T.

AU - Caretto, M.

AU - Sartori, E.

AU - Ferrari, F.

AU - Cianci, A.

AU - Sarpietro, G.

AU - Matarazzo, M. G.

AU - Giampaolino, P.

AU - Bifulco, G.

AU - Morelli, M.

AU - Dio, M. D.

AU - Ferrero, A.

AU - Biglia, N.

AU - Barra, F.

AU - Ferrero, S.

AU - Cianci, S.

AU - Chiantera, V.

AU - Sozzi, G.

AU - Ercoli, A.

AU - Schettini, S.

AU - Orlando, T.

AU - Cannone, F. G.

AU - Ettore, G.

AU - Puppo, A.

AU - Olearo, E.

AU - Leone, Roberti Maggiore U.

AU - Artuso, V.

AU - Palaia, I.

AU - Perniola, G.

AU - Tripodi, R.

AU - D'Auge, T. G.

AU - Cuccu, I.

AU - Fischetti, M.

AU - Santangelo, G.

AU - Casorelli, A.

AU - Giannini, A.

AU - D'Oria, O.

AU - Vizzielli, G.

AU - Restaino, S.

AU - Bergamini, A.

AU - Bocciolone, L.

AU - Plotti, F.

AU - Angioli, R.

AU - Mantovani, G.

AU - Ceccaroni, M.

AU - Cassini, C.

AU - Dominoni, M.

AU - Giambanco, L.

AU - Amodeo, S.

AU - Leo, L.

AU - Thommaset, R.

AU - Raimondo, D.

AU - Seracchioli, R.

AU - Malzoni, M.

AU - Falcone, F.

AU - Gorlero, F.

AU - Di, Luca M.

AU - Busato, E.

AU - Kilzie, S.

AU - Dell'Acqua, A.

AU - Scarfone, G.

AU - Vercellini, P.

AU - Petrillo, M.

AU - Capobianco, G.

AU - Ciavattini, A.

AU - Mereu, L.

AU - Scollo, P.

AU - Sorbi, F.

AU - Fambrini, M.

AU - Romano, F.

AU - Ricci, G.

AU - Trojano, G.

AU - Damiani, G. R.

AU - Consonni, R.

AU - Di, Lorenzo N.

AU - Lippolis, A.

AU - Tinelli, R.

AU - Aguzzoli, L.

AU - Mandato, V. D.

AU - Palomba, S.

AU - Tripodi, M.

AU - Calandra, D.

AU - Pellegrini, F.

AU - Zullo, F.

AU - SURICO, Daniela

AU - REMORGIDA, VALENTINO

AU - Ruscitto, F.

AU - Beretta, P.

AU - Vizza, E.

PY - 2022

Y1 - 2022

N2 - Background: To evaluate the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial on patterns of care and surgery-related morbidity in early-stage cervical cancer. Methods: This is a retrospective, a multi-institutional study evaluating 90-day surgery-related outcomes of patients undergoing treatment for early-stage cervical cancer before (period I: 01/01/2016–06/01/2018) and after (period II: 01/01/2019–06/01/2021) the publication of the results of the LACC trial. Results: Charts of 1295 patients were evaluated: 581 (44.9%) and 714 (55.1%) before and after the publication of the LACC trial, respectively. After the publication of the LACC trial, the number of patients treated with minimally invasive radical hysterectomy decreased from 64.9% to 30.4% (p < 0.001). Overall, 90-day complications occurred in 110 (18.9%) and 119 (16.6%) patients in the period I and period II, respectively (p = 0.795). Similarly, the number of severe (grade 3 or worse) complications did not differ between the two periods (38 (6.5%) vs. 37 (5.1%); p = 0.297). Overall and severe 90-day complications were consistent between periods even evaluating stage IA (p = 0.471), IB1 (p = 0.929), and IB2 (p = 0.074), separately. Conclusions: The present investigation highlighted that in referral centers the shift from minimally invasive to open radical hysterectomy does not influence 90-day surgery-related morbidity.

AB - Background: To evaluate the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial on patterns of care and surgery-related morbidity in early-stage cervical cancer. Methods: This is a retrospective, a multi-institutional study evaluating 90-day surgery-related outcomes of patients undergoing treatment for early-stage cervical cancer before (period I: 01/01/2016–06/01/2018) and after (period II: 01/01/2019–06/01/2021) the publication of the results of the LACC trial. Results: Charts of 1295 patients were evaluated: 581 (44.9%) and 714 (55.1%) before and after the publication of the LACC trial, respectively. After the publication of the LACC trial, the number of patients treated with minimally invasive radical hysterectomy decreased from 64.9% to 30.4% (p < 0.001). Overall, 90-day complications occurred in 110 (18.9%) and 119 (16.6%) patients in the period I and period II, respectively (p = 0.795). Similarly, the number of severe (grade 3 or worse) complications did not differ between the two periods (38 (6.5%) vs. 37 (5.1%); p = 0.297). Overall and severe 90-day complications were consistent between periods even evaluating stage IA (p = 0.471), IB1 (p = 0.929), and IB2 (p = 0.074), separately. Conclusions: The present investigation highlighted that in referral centers the shift from minimally invasive to open radical hysterectomy does not influence 90-day surgery-related morbidity.

KW - Complications

KW - Laparoscopy

KW - Morbidity

KW - Radical hysterectomy

KW - Complications

KW - Laparoscopy

KW - Morbidity

KW - Radical hysterectomy

UR - https://iris.uniupo.it/handle/11579/155602

U2 - 10.1016/j.ygyno.2022.07.022

DO - 10.1016/j.ygyno.2022.07.022

M3 - Article

SN - 0090-8258

VL - 166

SP - 561

EP - 566

JO - Gynecologic Oncology

JF - Gynecologic Oncology

IS - 3

ER -

Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer

Abstract

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Keywords

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