Powering tyrosol antioxidant capacity and osteogenic activity by biocatalytic polymerization

Stefano Antenucci, Lucia Panzella, Hermes Farina, Marco Aldo Ortenzi, Enrico Caneva, Simona Martinotti, Elia Ranzato, Bruno Burlando, Marco D'Ischia, Alessandra Napolitano, Luisella Verotta

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Oxidative polymerization of tyrosol by horseradish peroxidase (HRP)-H2O2 afforded an insoluble product (oligotyrosol, OligoTyr) consisting of mixture of linear oligomers (up to 11-mer) with limited benzylic branching points, as evidenced by ESI-MS and solid state 13C NMR analysis. OligoTyr proved to be significantly more active than tyrosol in several antioxidant assays and was not toxic to human osteosarcoma SaOS-2 cells, stimulating alkaline phosphatase (ALP) activity at day 7 in a similar manner as tyrosol. However, when loaded at 5% w/w into highly porous polylactic acid (PLA) scaffolds featuring hierarchical structures, OligoTyr caused a significant increase in the ALP activity of SaOS-2 cells compared to PLA alone, while tyrosol was completely inactive. A release of ca. 5% from PLA was determined after 1 week in a physiological medium. No significant influence on calcium release from PLA scaffolds containing 5% β-tricalcium phosphate was observed.

Lingua originaleInglese
pagine (da-a)2993-3002
Numero di pagine10
RivistaRSC Advances
Volume6
Numero di pubblicazione4
DOI
Stato di pubblicazionePubblicato - 2016

Fingerprint

Entra nei temi di ricerca di 'Powering tyrosol antioxidant capacity and osteogenic activity by biocatalytic polymerization'. Insieme formano una fingerprint unica.

Cita questo