Potential Histamine H2‐Receptor Antagonists: Synthesis and Pharmacological Activity of Derivatives Containing Acylamino‐furazan Moieties

G. Sorba, R. Fruttero, A. Di Stilo, A. Gasco, M. Orsetti

Risultato della ricerca: Contributo su rivistaArticolo di reviewpeer review

Abstract

Analogues of 3‐amino‐4‐[2‐[(5‐dimethylaminomethyl‐2‐furyl)methylthio] ethylamino]furazan (1) containing carbonyl groups joined to the amino functions linked to the furazan system have been synthetized and investigated for their H2‐antagonist properties on the isolated guinea pig right atrium. The presence of the carbonyl group lowers the activity in respect to the corresponding leads. The decrease in activity is only by 1‐2 orders of magnitude in the 3‐acylaminofurazan series versus inactivity in the 4‐acylamino isomers and in the diacylated series.

Lingua originaleInglese
pagine (da-a)151-155
Numero di pagine5
RivistaArchiv der Pharmazie
Volume325
Numero di pubblicazione3
DOI
Stato di pubblicazionePubblicato - 1992
Pubblicato esternamente

Fingerprint

Entra nei temi di ricerca di 'Potential Histamine H2‐Receptor Antagonists: Synthesis and Pharmacological Activity of Derivatives Containing Acylamino‐furazan Moieties'. Insieme formano una fingerprint unica.

Cita questo