Potential Histamine H2‐Receptor Antagonists: Analogues of Classical Antagonists Containing 4‐Substituted‐3‐Aminofurazan Moieties

Albino Defilippi; Giovanni Sorba; Rosella Calvino; Adele Garrone; Alberto Gasco; Marco Orsetti

doi:10.1002/ardp.19883210207

Potential Histamine H₂‐Receptor Antagonists: Analogues of Classical Antagonists Containing 4‐Substituted‐3‐Aminofurazan Moieties

Albino Defilippi
, Giovanni Sorba
, Rosella Calvino
, Adele Garrone
, Alberto Gasco
, Marco Orsetti

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Analogues of classical H₂‐receptor antagonists containing aminofurazan moieties as polar groups were synthesized and tested “in vitro” for their activities. Compounds containing 3‐amino‐4‐methylfurazan and 4‐amino‐3‐methylfuroxan substructures show good antagonistic properties. The compound containing the 3‐amino‐4‐phenylfurazan moiety is inactive. An SAR approach is discussed.

Lingua originale	Inglese
pagine (da-a)	77-80
Numero di pagine	4
Rivista	Archiv der Pharmazie
Volume	321
Numero di pubblicazione	2
DOI	https://doi.org/10.1002/ardp.19883210207
Stato di pubblicazione	Pubblicato - 1988
Pubblicato esternamente	Sì

Accesso al documento

10.1002/ardp.19883210207

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abstract = "Analogues of classical H2‐receptor antagonists containing aminofurazan moieties as polar groups were synthesized and tested “in vitro” for their activities. Compounds containing 3‐amino‐4‐methylfurazan and 4‐amino‐3‐methylfuroxan substructures show good antagonistic properties. The compound containing the 3‐amino‐4‐phenylfurazan moiety is inactive. An SAR approach is discussed.",

author = "Albino Defilippi and Giovanni Sorba and Rosella Calvino and Adele Garrone and Alberto Gasco and Marco Orsetti",

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AU - Calvino, Rosella

AU - Garrone, Adele

AU - Gasco, Alberto

AU - Orsetti, Marco

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AB - Analogues of classical H2‐receptor antagonists containing aminofurazan moieties as polar groups were synthesized and tested “in vitro” for their activities. Compounds containing 3‐amino‐4‐methylfurazan and 4‐amino‐3‐methylfuroxan substructures show good antagonistic properties. The compound containing the 3‐amino‐4‐phenylfurazan moiety is inactive. An SAR approach is discussed.

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