Potential histamine H2-receptor antagonists. Synthesis, structure and activity of a few open models related to classical H2-antagonists

G. Sorba; R. Fruttero; A. Gasco; M. Orsetti

Potential histamine H₂-receptor antagonists. Synthesis, structure and activity of a few open models related to classical H₂-antagonists

G. Sorba
, R. Fruttero
, A. Gasco
, M. Orsetti

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A few ethers and oximes structurally related to classical H₂-antagonists have been synthesized and tested for their in vitro H₂-antagonist activity. The compounds in which cyclic 'urea equivalent' groups are joined to a cyclohexylmethyl moiety showed a high increase of activity in comparison with the unsubstituted analogues. This finding supports the hypothesis of the existence of an accessorial binding area on H₂-receptor near the site fitted by cyclic 'urea equivalent' groups.

Lingua originale	Inglese
pagine (da-a)	1092-1096
Numero di pagine	5
Rivista	Arzneimittel-Forschung/Drug Research
Volume	39
Numero di pubblicazione	9
Stato di pubblicazione	Pubblicato - 1989
Pubblicato esternamente	Sì

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title = "Potential histamine H2-receptor antagonists. Synthesis, structure and activity of a few open models related to classical H2-antagonists",

abstract = "A few ethers and oximes structurally related to classical H2-antagonists have been synthesized and tested for their in vitro H2-antagonist activity. The compounds in which cyclic 'urea equivalent' groups are joined to a cyclohexylmethyl moiety showed a high increase of activity in comparison with the unsubstituted analogues. This finding supports the hypothesis of the existence of an accessorial binding area on H2-receptor near the site fitted by cyclic 'urea equivalent' groups.",

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AU - Fruttero, R.

AU - Gasco, A.

AU - Orsetti, M.

PY - 1989

Y1 - 1989

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AB - A few ethers and oximes structurally related to classical H2-antagonists have been synthesized and tested for their in vitro H2-antagonist activity. The compounds in which cyclic 'urea equivalent' groups are joined to a cyclohexylmethyl moiety showed a high increase of activity in comparison with the unsubstituted analogues. This finding supports the hypothesis of the existence of an accessorial binding area on H2-receptor near the site fitted by cyclic 'urea equivalent' groups.

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M3 - Article

SN - 0004-4172

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JO - Arzneimittel-Forschung/Drug Research

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IS - 9

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Potential histamine H2-receptor antagonists. Synthesis, structure and activity of a few open models related to classical H2-antagonists

Abstract

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Potential histamine H₂-receptor antagonists. Synthesis, structure and activity of a few open models related to classical H₂-antagonists