Potential histamine H2-receptor antagonists. Synthesis, structure and activity of a few open models related to classical H2-antagonists

G. Sorba, R. Fruttero, A. Gasco, M. Orsetti

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

A few ethers and oximes structurally related to classical H2-antagonists have been synthesized and tested for their in vitro H2-antagonist activity. The compounds in which cyclic 'urea equivalent' groups are joined to a cyclohexylmethyl moiety showed a high increase of activity in comparison with the unsubstituted analogues. This finding supports the hypothesis of the existence of an accessorial binding area on H2-receptor near the site fitted by cyclic 'urea equivalent' groups.

Lingua originaleInglese
pagine (da-a)1092-1096
Numero di pagine5
RivistaArzneimittel-Forschung/Drug Research
Volume39
Numero di pubblicazione9
Stato di pubblicazionePubblicato - 1989
Pubblicato esternamente

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