Abstract
A few ethers and oximes structurally related to classical H2-antagonists have been synthesized and tested for their in vitro H2-antagonist activity. The compounds in which cyclic 'urea equivalent' groups are joined to a cyclohexylmethyl moiety showed a high increase of activity in comparison with the unsubstituted analogues. This finding supports the hypothesis of the existence of an accessorial binding area on H2-receptor near the site fitted by cyclic 'urea equivalent' groups.
Lingua originale | Inglese |
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pagine (da-a) | 1092-1096 |
Numero di pagine | 5 |
Rivista | Arzneimittel-Forschung/Drug Research |
Volume | 39 |
Numero di pubblicazione | 9 |
Stato di pubblicazione | Pubblicato - 1989 |
Pubblicato esternamente | Sì |