TY - JOUR
T1 - Possible role of prolactin in the modification of medial basal hypothalamic glutamic acid decarboxylase activity
AU - Prato, Agata
AU - Clementi, Giuseppe
AU - Nicoletti, Ferdinanco
AU - Canonico, Pier Luigi
AU - Patti, Francesco
AU - Condorelli, Daniele Filippo
AU - Di Giorgio, Rosa Maria
AU - Drago, Filippo
PY - 1981/4/24
Y1 - 1981/4/24
N2 - The effects of acute and chronic injections of haloperidol, sulpiride and apomorphine on serum prolactin (PRL) levels and medial basal hypothalamus (MBH) glutamic acid decarboxylase (GAD) activity were investigated in male rats. Parallel changes in PRL and GAD activity were observed in acutely treated animals. Conversely, a return to normal of the GAD activity associated with high plasma PRL levels was induced by chronic haloperidol and sulpiride treatment. Results are discussed in the light of the possible existence of a hypothetical PRL-γ-aminobutyric acid (GABA) subsidiary feedback loop.
AB - The effects of acute and chronic injections of haloperidol, sulpiride and apomorphine on serum prolactin (PRL) levels and medial basal hypothalamus (MBH) glutamic acid decarboxylase (GAD) activity were investigated in male rats. Parallel changes in PRL and GAD activity were observed in acutely treated animals. Conversely, a return to normal of the GAD activity associated with high plasma PRL levels was induced by chronic haloperidol and sulpiride treatment. Results are discussed in the light of the possible existence of a hypothetical PRL-γ-aminobutyric acid (GABA) subsidiary feedback loop.
KW - GABA
KW - Glutamic acid decarboxylase
KW - Medial basal hypothalamus
KW - Prolactin
UR - https://www.scopus.com/pages/publications/0019464966
U2 - 10.1016/0014-2999(81)90404-0
DO - 10.1016/0014-2999(81)90404-0
M3 - Article
SN - 0014-2999
VL - 71
SP - 169
EP - 172
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -