Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes

Emiliano Fabiani; Francesco D'Alò; Alessandra Scardocci; Mariangela Greco; Annalisa Di Ruscio; Marianna Criscuolo; Luana Fianchi; Livio Pagano; Stefan Hohaus; Giuseppe Leone; Maria Teresa Voso

doi:10.1016/j.leukres.2008.10.012

Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes

Emiliano Fabiani
, Francesco D'Alò
, Alessandra Scardocci
, Mariangela Greco
, Annalisa Di Ruscio
, Marianna Criscuolo
, Luana Fianchi
, Livio Pagano
, Stefan Hohaus
, Giuseppe Leone
, Maria Teresa Voso

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other hand, the GSTP1-105Val allele was associated to an increased risk of MDS (O.R. 1.66; p = 0.04) and to higher probability of overall survival in the low/intermediate-1 IPSS risk group (p = 0.008). The GSTP1-Ile105Val polymorphism is likely to influence MDS risk and prognosis.

Lingua originale	Inglese
pagine (da-a)	1068-1071
Numero di pagine	4
Rivista	Leukemia Research
Volume	33
Numero di pubblicazione	8
DOI	https://doi.org/10.1016/j.leukres.2008.10.012
Stato di pubblicazione	Pubblicato - ago 2009
Pubblicato esternamente	Sì

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10.1016/j.leukres.2008.10.012

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@article{4040ce5e98d9498c80a33f4050d1da31,

title = "Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes",

abstract = "The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other hand, the GSTP1-105Val allele was associated to an increased risk of MDS (O.R. 1.66; p = 0.04) and to higher probability of overall survival in the low/intermediate-1 IPSS risk group (p = 0.008). The GSTP1-Ile105Val polymorphism is likely to influence MDS risk and prognosis.",

keywords = "DNA repair, Detoxification, Myelodysplastic Syndromes, Polymorphisms, Prognosis",

author = "Emiliano Fabiani and Francesco D'Al{\`o} and Alessandra Scardocci and Mariangela Greco and \{Di Ruscio\}, Annalisa and Marianna Criscuolo and Luana Fianchi and Livio Pagano and Stefan Hohaus and Giuseppe Leone and Voso, \{Maria Teresa\}",

note = "Funding Information: Funding: This work has been supported by grants from AIRC (Associazione Italiana per la Ricerca sul Cancro), M.I.U.R. (Ministero dell{\textquoteright}Istruzione, dell{\textquoteright}Universit{\`a} e della Ricerca Scientifica) and Fondazione Roma “Progetto cellule staminali, Una nuova frontiera nella ricerca biomedica”. ",

year = "2009",

month = aug,

doi = "10.1016/j.leukres.2008.10.012",

language = "English",

volume = "33",

pages = "1068--1071",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd.",

number = "8",

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TY - JOUR

T1 - Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes

AU - Fabiani, Emiliano

AU - D'Alò, Francesco

AU - Scardocci, Alessandra

AU - Greco, Mariangela

AU - Di Ruscio, Annalisa

AU - Criscuolo, Marianna

AU - Fianchi, Luana

AU - Pagano, Livio

AU - Hohaus, Stefan

AU - Leone, Giuseppe

AU - Voso, Maria Teresa

N1 - Funding Information: Funding: This work has been supported by grants from AIRC (Associazione Italiana per la Ricerca sul Cancro), M.I.U.R. (Ministero dell’Istruzione, dell’Università e della Ricerca Scientifica) and Fondazione Roma “Progetto cellule staminali, Una nuova frontiera nella ricerca biomedica”.

PY - 2009/8

Y1 - 2009/8

N2 - The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other hand, the GSTP1-105Val allele was associated to an increased risk of MDS (O.R. 1.66; p = 0.04) and to higher probability of overall survival in the low/intermediate-1 IPSS risk group (p = 0.008). The GSTP1-Ile105Val polymorphism is likely to influence MDS risk and prognosis.

AB - The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other hand, the GSTP1-105Val allele was associated to an increased risk of MDS (O.R. 1.66; p = 0.04) and to higher probability of overall survival in the low/intermediate-1 IPSS risk group (p = 0.008). The GSTP1-Ile105Val polymorphism is likely to influence MDS risk and prognosis.

KW - DNA repair

KW - Detoxification

KW - Myelodysplastic Syndromes

KW - Polymorphisms

KW - Prognosis

UR - https://www.scopus.com/pages/publications/67349137713

U2 - 10.1016/j.leukres.2008.10.012

DO - 10.1016/j.leukres.2008.10.012

M3 - Article

SN - 0145-2126

VL - 33

SP - 1068

EP - 1071

JO - Leukemia Research

JF - Leukemia Research

IS - 8

ER -

Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes

Abstract

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