Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents

Lyndsay M. Randolph; Clare L.M. Leguyader; Michael E. Hahn; Christopher M. Andolina; Joseph P. Patterson; Robert F. Mattrey; Jill E. Millstone; Mauro Botta; Miriam Scadeng; Nathan C. Gianneschi

doi:10.1039/c6sc00342g

Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents

Lyndsay M. Randolph, Clare L.M. Leguyader, Michael E. Hahn, Christopher M. Andolina, Joseph P. Patterson, Robert F. Mattrey, Jill E. Millstone, Mauro Botta, Miriam Scadeng, Nathan C. Gianneschi

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A Gd³⁺-coordinated polymerizable analogue of the MRI contrast agent Gd-DOTA was used to prepare amphiphilic block copolymers, with hydrophilic blocks composed entirely of the polymerized contrast agent. The resulting amphiphilic block copolymers assemble into nanoparticles (NPs) of spherical- or fibril-shape, each demonstrating enhanced relaxivity over Gd-DOTA. As an initial examination of their behavior in vivo, intraperitoneal (IP) injection of NPs into live mice was performed, showing long IP residence times, observed by MRI. Extended residence times for particles of well-defined morphology may represent a valuable design paradigm for treatment or diagnosis of peritoneal malignances.

Lingua originale	Inglese
pagine (da-a)	4230-4236
Numero di pagine	7
Rivista	Chemical Science
Volume	7
Numero di pubblicazione	7
DOI	https://doi.org/10.1039/c6sc00342g
Stato di pubblicazione	Pubblicato - 2016

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10.1039/c6sc00342g

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title = "Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents",

abstract = "A Gd3+-coordinated polymerizable analogue of the MRI contrast agent Gd-DOTA was used to prepare amphiphilic block copolymers, with hydrophilic blocks composed entirely of the polymerized contrast agent. The resulting amphiphilic block copolymers assemble into nanoparticles (NPs) of spherical- or fibril-shape, each demonstrating enhanced relaxivity over Gd-DOTA. As an initial examination of their behavior in vivo, intraperitoneal (IP) injection of NPs into live mice was performed, showing long IP residence times, observed by MRI. Extended residence times for particles of well-defined morphology may represent a valuable design paradigm for treatment or diagnosis of peritoneal malignances.",

author = "Randolph, {Lyndsay M.} and Leguyader, {Clare L.M.} and Hahn, {Michael E.} and Andolina, {Christopher M.} and Patterson, {Joseph P.} and Mattrey, {Robert F.} and Millstone, {Jill E.} and Mauro Botta and Miriam Scadeng and Gianneschi, {Nathan C.}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

doi = "10.1039/c6sc00342g",

language = "English",

volume = "7",

pages = "4230--4236",

journal = "Chemical Science",

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TY - JOUR

T1 - Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents

AU - Randolph, Lyndsay M.

AU - Leguyader, Clare L.M.

AU - Hahn, Michael E.

AU - Andolina, Christopher M.

AU - Patterson, Joseph P.

AU - Mattrey, Robert F.

AU - Millstone, Jill E.

AU - Botta, Mauro

AU - Scadeng, Miriam

AU - Gianneschi, Nathan C.

PY - 2016

Y1 - 2016

N2 - A Gd3+-coordinated polymerizable analogue of the MRI contrast agent Gd-DOTA was used to prepare amphiphilic block copolymers, with hydrophilic blocks composed entirely of the polymerized contrast agent. The resulting amphiphilic block copolymers assemble into nanoparticles (NPs) of spherical- or fibril-shape, each demonstrating enhanced relaxivity over Gd-DOTA. As an initial examination of their behavior in vivo, intraperitoneal (IP) injection of NPs into live mice was performed, showing long IP residence times, observed by MRI. Extended residence times for particles of well-defined morphology may represent a valuable design paradigm for treatment or diagnosis of peritoneal malignances.

AB - A Gd3+-coordinated polymerizable analogue of the MRI contrast agent Gd-DOTA was used to prepare amphiphilic block copolymers, with hydrophilic blocks composed entirely of the polymerized contrast agent. The resulting amphiphilic block copolymers assemble into nanoparticles (NPs) of spherical- or fibril-shape, each demonstrating enhanced relaxivity over Gd-DOTA. As an initial examination of their behavior in vivo, intraperitoneal (IP) injection of NPs into live mice was performed, showing long IP residence times, observed by MRI. Extended residence times for particles of well-defined morphology may represent a valuable design paradigm for treatment or diagnosis of peritoneal malignances.

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U2 - 10.1039/c6sc00342g

DO - 10.1039/c6sc00342g

M3 - Article

SN - 2041-6520

VL - 7

SP - 4230

EP - 4236

JO - Chemical Science

JF - Chemical Science

IS - 7

ER -

Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents

Abstract

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