Polyhydroxylated GdDTPA-derivatives as high relaxivity magnetic resonance imaging contrast agents

Lorenzo Tei, Alessandro Barge, Matteo Galli, Roberta Pinalli, Luciano Lattuada, Eliana Gianolio, Silvio Aime

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The search for new MRI agents endowed with high relaxivity at the magnetic field strength of clinical scanners (1.5-3 T) is still receiving great attention from researchers involved in the development of new probes. Such Gd(iii) complexes should combine a fast inner-sphere water exchange rate (kex) with an enhanced contribution from water molecules in the second and outer coordination spheres. In the present work, dendrimeric-like structures were synthesized by coupling diethylenetriaminepentaacetic acid (DTPA) and its mono-methylphosphonic derivative (P-DTPA) with two differently branched, highly hydrophilic, gluconyl moieties. A 1H and 17O NMR relaxometric study on the corresponding Gd(iii) complexes reveals that the Gd-P-DTPA-polyol complex displays very high relaxivities (around 20 mM-1 s-1 at 298 K) over the 0.5-3 T range of field strengths as a result of a fast kex and the presence of a strong second sphere contribution.

Lingua originaleInglese
pagine (da-a)74734-74743
Numero di pagine10
RivistaRSC Advances
Volume5
Numero di pubblicazione91
DOI
Stato di pubblicazionePubblicato - 28 ago 2015

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