Polycyclic diterpenoids from Euphorbia characias

Giovanni Appendino; Emanuela Belloro; Gian Cesare Tron; Jasmin Jakupovic; Mauro Ballero

doi:10.1016/S0367-326X(99)00134-3

Polycyclic diterpenoids from Euphorbia characias

Giovanni Appendino
, Emanuela Belloro
, Gian Cesare Tron
, Jasmin Jakupovic
, Mauro Ballero

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

In addition to widespread flavonoids, a collection of Euphorbia characias from Sardinia afforded 13 oxygenated diterpenoids of the atisane, abietane, pimarane, and kaurane type. Four of these compounds (1, 3a, 7a,b) are new. The accumulation of substantial amounts of biologically active diterpenoids of limited availability, like ent-atisanes endowed with anti-HIV activity and ent-abietanolides active on the central nervous system, makes E. characias an interesting source of lead compounds for biomedical research. (C) 2000 Elsevier Science B.V.

Lingua originale	Inglese
pagine (da-a)	134-142
Numero di pagine	9
Rivista	Fitoterapia
Volume	71
Numero di pubblicazione	2
DOI	https://doi.org/10.1016/S0367-326X(99)00134-3
Stato di pubblicazione	Pubblicato - 1 apr 2000
Pubblicato esternamente	Sì

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title = "Polycyclic diterpenoids from Euphorbia characias",

abstract = "In addition to widespread flavonoids, a collection of Euphorbia characias from Sardinia afforded 13 oxygenated diterpenoids of the atisane, abietane, pimarane, and kaurane type. Four of these compounds (1, 3a, 7a,b) are new. The accumulation of substantial amounts of biologically active diterpenoids of limited availability, like ent-atisanes endowed with anti-HIV activity and ent-abietanolides active on the central nervous system, makes E. characias an interesting source of lead compounds for biomedical research. (C) 2000 Elsevier Science B.V.",

keywords = "Diterpenes, Euphorbia characias, ent- Pimaranes, ent-Abietanolides, ent-Atisanes",

author = "Giovanni Appendino and Emanuela Belloro and \{Cesare Tron\}, Gian and Jasmin Jakupovic and Mauro Ballero",

note = "Funding Information: This work was supported by EU (Contract ERBFAIR CT 1781) and by MURST (Fondi 40\%, Progetto Chimica dei Composti Organici di Interesse Biologico). We warmly thank Dr Raffaele Sestu and the Pro Loco Arzana (NU) for their help and hospitality during the collection of the plant material. ",

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doi = "10.1016/S0367-326X(99)00134-3",

language = "English",

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TY - JOUR

T1 - Polycyclic diterpenoids from Euphorbia characias

AU - Appendino, Giovanni

AU - Belloro, Emanuela

AU - Cesare Tron, Gian

AU - Jakupovic, Jasmin

AU - Ballero, Mauro

N1 - Funding Information: This work was supported by EU (Contract ERBFAIR CT 1781) and by MURST (Fondi 40%, Progetto Chimica dei Composti Organici di Interesse Biologico). We warmly thank Dr Raffaele Sestu and the Pro Loco Arzana (NU) for their help and hospitality during the collection of the plant material.

PY - 2000/4/1

Y1 - 2000/4/1

N2 - In addition to widespread flavonoids, a collection of Euphorbia characias from Sardinia afforded 13 oxygenated diterpenoids of the atisane, abietane, pimarane, and kaurane type. Four of these compounds (1, 3a, 7a,b) are new. The accumulation of substantial amounts of biologically active diterpenoids of limited availability, like ent-atisanes endowed with anti-HIV activity and ent-abietanolides active on the central nervous system, makes E. characias an interesting source of lead compounds for biomedical research. (C) 2000 Elsevier Science B.V.

AB - In addition to widespread flavonoids, a collection of Euphorbia characias from Sardinia afforded 13 oxygenated diterpenoids of the atisane, abietane, pimarane, and kaurane type. Four of these compounds (1, 3a, 7a,b) are new. The accumulation of substantial amounts of biologically active diterpenoids of limited availability, like ent-atisanes endowed with anti-HIV activity and ent-abietanolides active on the central nervous system, makes E. characias an interesting source of lead compounds for biomedical research. (C) 2000 Elsevier Science B.V.

KW - Diterpenes

KW - Euphorbia characias

KW - ent- Pimaranes

KW - ent-Abietanolides

KW - ent-Atisanes

UR - https://www.scopus.com/pages/publications/0034175910

U2 - 10.1016/S0367-326X(99)00134-3

DO - 10.1016/S0367-326X(99)00134-3

M3 - Article

SN - 0367-326X

VL - 71

SP - 134

EP - 142

JO - Fitoterapia

JF - Fitoterapia

IS - 2

ER -

Polycyclic diterpenoids from Euphorbia characias

Abstract

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