TY - JOUR
T1 - Polycatechol Nanoparticle MRI Contrast Agents
AU - Li, Yiwen
AU - Huang, Yuran
AU - Wang, Zhao
AU - Carniato, Fabio
AU - Xie, Yijun
AU - Patterson, Joseph P.
AU - Thompson, Matthew P.
AU - Andolina, Christopher M.
AU - Ditri, Treffly B.
AU - Millstone, Jill E.
AU - Figueroa, Joshua S.
AU - Rinehart, Jeffrey D.
AU - Scadeng, Miriam
AU - Botta, Mauro
AU - Gianneschi, Nathan C.
N1 - Publisher Copyright:
© 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2016/2/3
Y1 - 2016/2/3
N2 - Amphiphilic triblock copolymers containing FeIII-catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles (SMN and CMN, respectively) are described as new T 1-weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of magnetic field strengths. Interestingly, shape-dependent behavior is observed in terms of the particles' interactions with HeLa cells, with CMN exhibiting enhanced uptake and contrast via magnetic resonance imaging (MRI) compared with SMN. These results suggest that control over soft nanoparticle shape will provide an avenue for optimization of particle-based contrast agents as biodiagnostics. The polycatechol nanoparticles are proposed as suitable for preclinical investigations into their viability as gadolinium-free, safe, and effective imaging agents for MRI contrast enhancement.
AB - Amphiphilic triblock copolymers containing FeIII-catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles (SMN and CMN, respectively) are described as new T 1-weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of magnetic field strengths. Interestingly, shape-dependent behavior is observed in terms of the particles' interactions with HeLa cells, with CMN exhibiting enhanced uptake and contrast via magnetic resonance imaging (MRI) compared with SMN. These results suggest that control over soft nanoparticle shape will provide an avenue for optimization of particle-based contrast agents as biodiagnostics. The polycatechol nanoparticles are proposed as suitable for preclinical investigations into their viability as gadolinium-free, safe, and effective imaging agents for MRI contrast enhancement.
KW - contrast agents relaxivity
KW - melanin
KW - micelles
KW - polycatechols
UR - http://www.scopus.com/inward/record.url?scp=84956875089&partnerID=8YFLogxK
U2 - 10.1002/smll.201502754
DO - 10.1002/smll.201502754
M3 - Article
SN - 1613-6810
VL - 12
SP - 668
EP - 677
JO - Small
JF - Small
IS - 5
ER -