Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line

Antonio Caldarelli; Valeria De Biasio; Giovanni B. Giovenzana; Gianpiero Mastronardo; Roberto Negri

doi:10.1007/s11030-014-9519-5

Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line

Antonio Caldarelli
, Valeria De Biasio
, Giovanni B. Giovenzana
, Gianpiero Mastronardo
, Roberto Negri

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Cytotoxicity in the mu M range was observed in cancer cell lines treated with N,N,N',N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.

Lingua originale	Inglese
pagine (da-a)	879-886
Numero di pagine	8
Rivista	Molecular Diversity
Volume	18
Numero di pubblicazione	4
DOI	https://doi.org/10.1007/s11030-014-9519-5
Stato di pubblicazione	Pubblicato - 9 ott 2014

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10.1007/s11030-014-9519-5

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title = "Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line",

abstract = "Cytotoxicity in the μM range was observed in cancer cell lines treated with N,N,N' ,N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.",

keywords = "Cytotoxicity, G1 phase arrest, SAR, Tetrabenzyldiaminocyclopentenone",

author = "Antonio Caldarelli and \{De Biasio\}, Valeria and Giovenzana, \{Giovanni B.\} and Gianpiero Mastronardo and Roberto Negri",

note = "Publisher Copyright: {\textcopyright} 2014, Springer International Publishing Switzerland.",

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doi = "10.1007/s11030-014-9519-5",

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T1 - Polybenzylated alicyclic 1,2-diamines

T2 - cytotoxicity and G1 phase arrest in cancer cell line

AU - Caldarelli, Antonio

AU - De Biasio, Valeria

AU - Giovenzana, Giovanni B.

AU - Mastronardo, Gianpiero

AU - Negri, Roberto

PY - 2014/10/9

Y1 - 2014/10/9

N2 - Cytotoxicity in the μM range was observed in cancer cell lines treated with N,N,N' ,N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.

AB - Cytotoxicity in the μM range was observed in cancer cell lines treated with N,N,N' ,N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.

KW - Cytotoxicity

KW - G1 phase arrest

KW - SAR

KW - Tetrabenzyldiaminocyclopentenone

UR - https://www.scopus.com/pages/publications/84910016871

U2 - 10.1007/s11030-014-9519-5

DO - 10.1007/s11030-014-9519-5

M3 - Article

SN - 1381-1991

VL - 18

SP - 879

EP - 886

JO - Molecular Diversity

JF - Molecular Diversity

IS - 4

ER -

Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line

Abstract

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