Abstract
In this work platelet lysate (PL) and adipose-derived mesenchymal stromal cells (ASCs) seeded on nonwoven fibroin mats were in vitro and in vivo evaluated for tissue regenerative applications. Nonwoven mats obtained by a large scale water entanglement technique were characterized for their physico-chemical properties. Results indicated a high purity of fibroin fibers, their stability after sterilization process and appropriate technological properties suitable for tissue engineering. Moreover, the scaffolds in vitro supported adhesion and migration of ASCs and the presence of PL improved the cell proliferation. The products were then applied on epithelial/dermal wounds carried out on the dorsal surface of rabbit: the skin reparative process was solved in 9 days, with a completely restitutio ad integrum of the epithelium in animals treated with PL alone; ASCs did not further improve the wound healing.
Lingua originale | Inglese |
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Numero di articolo | 42942 |
Rivista | Journal of Applied Polymer Science |
Volume | 133 |
Numero di pubblicazione | 5 |
DOI | |
Stato di pubblicazione | Pubblicato - 1 feb 2016 |
Pubblicato esternamente | Sì |