Platelet lysate and adipose mesenchymal stromal cells on silk fibroin nonwoven mats for wound healing

Chlapanidas Theodora, Perteghella Sara, Faragò Silvio, Boschi Alessandra, Giuseppe Tripodo, Vigani Barbara, Crivelli Barbara, Renzi Sabrina, Dotti Silvia, Preda Stefania, Marazzi Mario, Torre Maria Luisa, Ferrari Maura

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Abstract

In this work platelet lysate (PL) and adipose-derived mesenchymal stromal cells (ASCs) seeded on nonwoven fibroin mats were in vitro and in vivo evaluated for tissue regenerative applications. Nonwoven mats obtained by a large scale water entanglement technique were characterized for their physico-chemical properties. Results indicated a high purity of fibroin fibers, their stability after sterilization process and appropriate technological properties suitable for tissue engineering. Moreover, the scaffolds in vitro supported adhesion and migration of ASCs and the presence of PL improved the cell proliferation. The products were then applied on epithelial/dermal wounds carried out on the dorsal surface of rabbit: the skin reparative process was solved in 9 days, with a completely restitutio ad integrum of the epithelium in animals treated with PL alone; ASCs did not further improve the wound healing.

Lingua originaleInglese
Numero di articolo42942
RivistaJournal of Applied Polymer Science
Volume133
Numero di pubblicazione5
DOI
Stato di pubblicazionePubblicato - 1 feb 2016
Pubblicato esternamente

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