TY - JOUR
T1 - Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors
T2 - EPIC-CVD case-cohort study
AU - Fortuin-De Smidt, Melony C.
AU - Sewe, Maquins Odhiambo
AU - Lassale, Camille
AU - Weiderpass, Elisabete
AU - Andersson, Jonas
AU - Huerta, José María
AU - Ekelund, Ulf
AU - Aleksandrova, Krasimira
AU - Tong, Tammy Y.N.
AU - Dahm, Christina C.
AU - Tjønneland, Anne
AU - Kyrø, Cecilie
AU - Steindorf, Karen
AU - Schulze, Matthias B.
AU - Katzke, Verena
AU - Sacerdote, Carlotta
AU - Agnoli, Claudia
AU - Masala, Giovanna
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Boer, Jolanda M.A.
AU - Onland-Moret, N. Charlotte
AU - Wendel-Vos, G. C.Wanda
AU - van der Schouw, Yvonne T.
AU - Borch, Kristin Benjaminsen
AU - Agudo, Antonio
AU - Petrova, Dafina
AU - Chirlaque, María Dolores
AU - Conchi, Moreno Iribas
AU - Amiano, Pilar
AU - Melander, Olle
AU - Heath, Alicia K.
AU - Aune, Dagfinn
AU - Forouhi, Nita G.
AU - Langenberg, Claudia
AU - Brage, Soren
AU - Riboli, Elio
AU - Wareham, Nicholas J.
AU - Danesh, John
AU - Butterworth, Adam S.
AU - Wennberg, Patrik
N1 - Publisher Copyright:
© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Aims This study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors. Methods EPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected and results sub-cohort nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Self-reported physical activity was summarized using the Cambridge physical activity index (inactive, moderately inactive, moderately active, and active). Participants were categorized into sub-groups based on the presence or the absence of the following risk factors: obesity (body mass index ≥30 kg/m2), hypercholesterolaemia (total cholesterol ≥6.2 mmol/L), history of diabetes, hypertension (self-reported or ≥140/90 mmHg), and current smoking. Prentice-weighted Cox regression was used to assess the association between physical activity and incident CHD events (non-fatal and fatal). Compared to inactive participants without the respective CHD risk factor (referent), excess CHD risk was highest in physically inactive and lowest in moderately active participants with CHD risk factors. Corresponding excess CHD risk estimates amongst those with obesity were 47% [95% confidence interval (CI) 32–64%] and 21% (95%CI 2–44%), with hypercholesterolaemia were 80% (95%CI 55–108%) and 48% (95%CI 22–81%), with hypertension were 80% (95%CI 65–96%) and 49% (95%CI 28–74%), with diabetes were 142% (95%CI 63–260%), and 100% (95%CI 32–204%), and amongst smokers were 152% (95%CI 122–186%) and 109% (95%CI 74–150%). Conclusions In people with CHD risk factors, moderate physical activity, equivalent to 40 mins of walking per day, attenuates but does not completely offset CHD risk.
AB - Aims This study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors. Methods EPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected and results sub-cohort nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Self-reported physical activity was summarized using the Cambridge physical activity index (inactive, moderately inactive, moderately active, and active). Participants were categorized into sub-groups based on the presence or the absence of the following risk factors: obesity (body mass index ≥30 kg/m2), hypercholesterolaemia (total cholesterol ≥6.2 mmol/L), history of diabetes, hypertension (self-reported or ≥140/90 mmHg), and current smoking. Prentice-weighted Cox regression was used to assess the association between physical activity and incident CHD events (non-fatal and fatal). Compared to inactive participants without the respective CHD risk factor (referent), excess CHD risk was highest in physically inactive and lowest in moderately active participants with CHD risk factors. Corresponding excess CHD risk estimates amongst those with obesity were 47% [95% confidence interval (CI) 32–64%] and 21% (95%CI 2–44%), with hypercholesterolaemia were 80% (95%CI 55–108%) and 48% (95%CI 22–81%), with hypertension were 80% (95%CI 65–96%) and 49% (95%CI 28–74%), with diabetes were 142% (95%CI 63–260%), and 100% (95%CI 32–204%), and amongst smokers were 152% (95%CI 122–186%) and 109% (95%CI 74–150%). Conclusions In people with CHD risk factors, moderate physical activity, equivalent to 40 mins of walking per day, attenuates but does not completely offset CHD risk.
UR - https://www.scopus.com/pages/publications/85136552203
U2 - 10.1093/eurjpc/zwac055
DO - 10.1093/eurjpc/zwac055
M3 - Article
SN - 2047-4873
VL - 29
SP - 1618
EP - 1629
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
IS - 12
ER -
