Photochemistry of Cannabidiol (CBD) Revised. A Combined Preparative and Spectrometric Investigation

Paolo Seccamani; Chiara Franco; Stefano Protti; Alessio Porta; Antonella Profumo; Diego Caprioglio; Stefano Salamone; Barbara Mannucci; Daniele Merli

doi:10.1021/acs.jnatprod.1c00567

Photochemistry of Cannabidiol (CBD) Revised. A Combined Preparative and Spectrometric Investigation

Paolo Seccamani, Chiara Franco, Stefano Protti, Alessio Porta, Antonella Profumo, Diego Caprioglio, Stefano Salamone, Barbara Mannucci, Daniele Merli

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo di review › peer review

Abstract

Cannabis is a plant with an astonishing ability to biosynthesize cannabinoids, and more than 100 molecules belonging to this class have been isolated. Among them in recent years cannabidiol (CBD) has received the interest of pharmacology as the major nonpsychotropic cannabinoid with many potential clinical applications. Although the reactivity of CBD has been widely investigated, only little attention has been given to the possible photodegradation of this cannabinoid, and the data available in the literature are outdated and, in some cases, conflicting. The aim of the present work is providing a characterization of the photochemical behavior of CBD in organic solvents, through a detailed GC-MS analyses, isolation, and NMR characterization of the photoproducts obtained.

Lingua originale	Inglese
pagine (da-a)	2858-2865
Numero di pagine	8
Rivista	Journal of Natural Products
Volume	84
Numero di pubblicazione	11
DOI	https://doi.org/10.1021/acs.jnatprod.1c00567
Stato di pubblicazione	Pubblicato - 26 nov 2021

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10.1021/acs.jnatprod.1c00567

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abstract = "Cannabis is a plant with an astonishing ability to biosynthesize cannabinoids, and more than 100 molecules belonging to this class have been isolated. Among them in recent years cannabidiol (CBD) has received the interest of pharmacology as the major nonpsychotropic cannabinoid with many potential clinical applications. Although the reactivity of CBD has been widely investigated, only little attention has been given to the possible photodegradation of this cannabinoid, and the data available in the literature are outdated and, in some cases, conflicting. The aim of the present work is providing a characterization of the photochemical behavior of CBD in organic solvents, through a detailed GC-MS analyses, isolation, and NMR characterization of the photoproducts obtained.",

author = "Paolo Seccamani and Chiara Franco and Stefano Protti and Alessio Porta and Antonella Profumo and Diego Caprioglio and Stefano Salamone and Barbara Mannucci and Daniele Merli",

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T1 - Photochemistry of Cannabidiol (CBD) Revised. A Combined Preparative and Spectrometric Investigation

AU - Seccamani, Paolo

AU - Franco, Chiara

AU - Protti, Stefano

AU - Porta, Alessio

AU - Profumo, Antonella

AU - Caprioglio, Diego

AU - Salamone, Stefano

AU - Mannucci, Barbara

AU - Merli, Daniele

PY - 2021/11/26

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N2 - Cannabis is a plant with an astonishing ability to biosynthesize cannabinoids, and more than 100 molecules belonging to this class have been isolated. Among them in recent years cannabidiol (CBD) has received the interest of pharmacology as the major nonpsychotropic cannabinoid with many potential clinical applications. Although the reactivity of CBD has been widely investigated, only little attention has been given to the possible photodegradation of this cannabinoid, and the data available in the literature are outdated and, in some cases, conflicting. The aim of the present work is providing a characterization of the photochemical behavior of CBD in organic solvents, through a detailed GC-MS analyses, isolation, and NMR characterization of the photoproducts obtained.

AB - Cannabis is a plant with an astonishing ability to biosynthesize cannabinoids, and more than 100 molecules belonging to this class have been isolated. Among them in recent years cannabidiol (CBD) has received the interest of pharmacology as the major nonpsychotropic cannabinoid with many potential clinical applications. Although the reactivity of CBD has been widely investigated, only little attention has been given to the possible photodegradation of this cannabinoid, and the data available in the literature are outdated and, in some cases, conflicting. The aim of the present work is providing a characterization of the photochemical behavior of CBD in organic solvents, through a detailed GC-MS analyses, isolation, and NMR characterization of the photoproducts obtained.

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DO - 10.1021/acs.jnatprod.1c00567

M3 - Review article

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ER -

Photochemistry of Cannabidiol (CBD) Revised. A Combined Preparative and Spectrometric Investigation

Abstract

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