Photoacoustic ratiometric assessment of mitoxantrone release from theranostic ICG-conjugated mesoporous silica nanoparticles

Giuseppe Ferrauto; Fabio Carniato; Enza Di Gregorio; Mauro Botta; Lorenzo Tei

doi:10.1039/c9nr06524e

Photoacoustic ratiometric assessment of mitoxantrone release from theranostic ICG-conjugated mesoporous silica nanoparticles

Giuseppe Ferrauto
, Fabio Carniato
, Enza Di Gregorio
, Mauro Botta
, Lorenzo Tei

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A theranostic nanosystem based on indocyanine green (ICG) covalently conjugated to mesoporous silica nanoparticles (MSNs) loaded with the anticancer drug mitoxantrone (MTX) is proposed as an innovative photoacoustic probe. Taking advantage of the characteristic PA signal displayed by both ICG and MTX, a PA-ratiometric approach was applied to assess the drug release profile from the MSNs. After complete in vitro characterization of the nanoprobe, a proof-of-concept study has been carried out in tumour-bearing mice to evaluate in vivo its effectiveness for cancer imaging and chemotherapeutic agent delivery.

Lingua originale	Inglese
pagine (da-a)	18031-18036
Numero di pagine	6
Rivista	Nanoscale
Volume	11
Numero di pubblicazione	39
DOI	https://doi.org/10.1039/c9nr06524e
Stato di pubblicazione	Pubblicato - 21 ott 2019

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title = "Photoacoustic ratiometric assessment of mitoxantrone release from theranostic ICG-conjugated mesoporous silica nanoparticles",

abstract = "A theranostic nanosystem based on indocyanine green (ICG) covalently conjugated to mesoporous silica nanoparticles (MSNs) loaded with the anticancer drug mitoxantrone (MTX) is proposed as an innovative photoacoustic probe. Taking advantage of the characteristic PA signal displayed by both ICG and MTX, a PA-ratiometric approach was applied to assess the drug release profile from the MSNs. After complete in vitro characterization of the nanoprobe, a proof-of-concept study has been carried out in tumour-bearing mice to evaluate in vivo its effectiveness for cancer imaging and chemotherapeutic agent delivery.",

author = "Giuseppe Ferrauto and Fabio Carniato and \{Di Gregorio\}, Enza and Mauro Botta and Lorenzo Tei",

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year = "2019",

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doi = "10.1039/c9nr06524e",

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AU - Ferrauto, Giuseppe

AU - Carniato, Fabio

AU - Di Gregorio, Enza

AU - Botta, Mauro

AU - Tei, Lorenzo

PY - 2019/10/21

Y1 - 2019/10/21

N2 - A theranostic nanosystem based on indocyanine green (ICG) covalently conjugated to mesoporous silica nanoparticles (MSNs) loaded with the anticancer drug mitoxantrone (MTX) is proposed as an innovative photoacoustic probe. Taking advantage of the characteristic PA signal displayed by both ICG and MTX, a PA-ratiometric approach was applied to assess the drug release profile from the MSNs. After complete in vitro characterization of the nanoprobe, a proof-of-concept study has been carried out in tumour-bearing mice to evaluate in vivo its effectiveness for cancer imaging and chemotherapeutic agent delivery.

AB - A theranostic nanosystem based on indocyanine green (ICG) covalently conjugated to mesoporous silica nanoparticles (MSNs) loaded with the anticancer drug mitoxantrone (MTX) is proposed as an innovative photoacoustic probe. Taking advantage of the characteristic PA signal displayed by both ICG and MTX, a PA-ratiometric approach was applied to assess the drug release profile from the MSNs. After complete in vitro characterization of the nanoprobe, a proof-of-concept study has been carried out in tumour-bearing mice to evaluate in vivo its effectiveness for cancer imaging and chemotherapeutic agent delivery.

UR - https://www.scopus.com/pages/publications/85073124583

U2 - 10.1039/c9nr06524e

DO - 10.1039/c9nr06524e

M3 - Article

SN - 2040-3364

VL - 11

SP - 18031

EP - 18036

JO - Nanoscale

JF - Nanoscale

IS - 39

ER -

Photoacoustic ratiometric assessment of mitoxantrone release from theranostic ICG-conjugated mesoporous silica nanoparticles

Abstract

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