Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22

Antonio P. Palumbo; Mario Boccadoro; Silvano Battaglio; Paolo Corradini; Bruna Giovinazzo; Giancarlo Avanzi; Giuseppe Ponzio

doi:10.1016/0165-4608(89)90232-X

Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22

Antonio P. Palumbo
, Mario Boccadoro
, Silvano Battaglio
, Paolo Corradini
, Bruna Giovinazzo
, Giancarlo Avanzi
, Giuseppe Ponzio

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).

Lingua originale	Inglese
pagine (da-a)	77-80
Numero di pagine	4
Rivista	Cancer Genetics and Cytogenetics
Volume	39
Numero di pubblicazione	1
DOI	https://doi.org/10.1016/0165-4608(89)90232-X
Stato di pubblicazione	Pubblicato - mag 1989
Pubblicato esternamente	Sì

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title = "Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22",

abstract = "We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).",

author = "Palumbo, \{Antonio P.\} and Mario Boccadoro and Silvano Battaglio and Paolo Corradini and Bruna Giovinazzo and Giancarlo Avanzi and Giuseppe Ponzio",

year = "1989",

month = may,

doi = "10.1016/0165-4608(89)90232-X",

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T1 - Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22

AU - Palumbo, Antonio P.

AU - Boccadoro, Mario

AU - Battaglio, Silvano

AU - Corradini, Paolo

AU - Giovinazzo, Bruna

AU - Avanzi, Giancarlo

AU - Ponzio, Giuseppe

PY - 1989/5

Y1 - 1989/5

N2 - We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).

AB - We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).

UR - https://www.scopus.com/pages/publications/0024348832

U2 - 10.1016/0165-4608(89)90232-X

DO - 10.1016/0165-4608(89)90232-X

M3 - Article

SN - 0165-4608

VL - 39

SP - 77

EP - 80

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22

Abstract

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