Pharmacokinetics of some cephalosporins in normal and nephrectomized rabbits

M. Eandi, I. Viano, M. Santiano

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The authors made a pharmacokinetic study of the cephalosporins cephazolin, cephaloridine, cefoperazone, and cefuroxime in the rabbit. They computed the pharmacokinetic parameters of a two-compartment open model from the plasma concentration time curves obtained at different increasing doses. Cephazolin, cephaloridine and cefoperazone demonstrated dose dependent kinetics since the constants of apparent rate of elimination and apparent volume of distribution varied with the doses. In order to evaluate the extra-renal rate of elimination, they performed pharmacokinetic analysis on the same animals after nephrectomy. While cephazolin, cephaloridine and cefuroxime were eliminated primarily through the kidneys, cefoperazone was largerly eliminated by extrarenal pathways.

Lingua originaleInglese
pagine (da-a)179-184
Numero di pagine6
RivistaMethods and Findings in Experimental and Clinical Pharmacology
Volume4
Numero di pubblicazione3
Stato di pubblicazionePubblicato - 1982
Pubblicato esternamente

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