TY - JOUR
T1 - Pharmacokinetic Changes during Pregnancy According to Genetic Variants: A Prospective Study in HIV-infected Patients Receiving Atazanavir/Ritonavir
AU - Focà, Emanuele
AU - CALCAGNO, Andrea
AU - Bonito, Andrea
AU - Cusato, Jessica
AU - Domenighini, Elisabetta
AU - D'Avolio, Antonio
AU - Roldan, Eugenia Quiros
AU - Trentini, Laura
AU - Castelnuovo, Filippo
AU - Perri, Giovanni Di
AU - Castelli, Francesco
AU - Bonora, Stefano
PY - 2018
Y1 - 2018
N2 - Atazanavir/ritonavir concentrations change over pregnancy in HIV-positive patients; the impact of genetic variants is unknown. 20 patients were enrolled: antiretrovirals' plasma and intracellular concentrations were measured in addition to single nucleotide polymorphisms in transport affecting genes. Linear logistic regression showed that genetic variants in organic-anion-transporter-1B1 and pregnane-X-receptor encoding genes affected third trimester atazanavir exposure. In this prospective study genetic variants partially explained the observed inter-patient variability in third-trimester antiretrovirals' exposure.
AB - Atazanavir/ritonavir concentrations change over pregnancy in HIV-positive patients; the impact of genetic variants is unknown. 20 patients were enrolled: antiretrovirals' plasma and intracellular concentrations were measured in addition to single nucleotide polymorphisms in transport affecting genes. Linear logistic regression showed that genetic variants in organic-anion-transporter-1B1 and pregnane-X-receptor encoding genes affected third trimester atazanavir exposure. In this prospective study genetic variants partially explained the observed inter-patient variability in third-trimester antiretrovirals' exposure.
UR - https://iris.uniupo.it/handle/11579/217001
U2 - 10.1128/AAC.00309-18
DO - 10.1128/AAC.00309-18
M3 - Article
SN - 0066-4804
VL - 1
SP - 1
EP - 5
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 1
ER -
