Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia

Jessica Cusato; Lucio Boglione; Amedeo De Nicolò; Chiara Simona Cardellino; Chiara Carcieri; Giuseppe Cariti; Giovanni Di Perri; Antonio D'Avolio

doi:10.2217/pgs-2016-0040

Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia

Jessica Cusato, Lucio Boglione, Amedeo De Nicolò, Chiara Simona Cardellino, Chiara Carcieri, Giuseppe Cariti, Giovanni Di Perri, Antonio D'Avolio

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Aim: Mixed cryoglobulinemia (MC) is an extra hepatic hepatitis C virus related problem and different studies suggested genetics' role in predicting this complication. We evaluated the influence of SNPs in IL-28B, SLC29A1, SLC28A2, NT5C2, HNF4 and ABCB1 genes in MC prediction. Patients & methods: SNPs were evaluated through real-time PCR. Results: ABCB1 (gene encoding P-glycoprotein) 3435C>T SNP was associated with MC presence (p = 0.034): related to T allele carriers (CC vs CT/TT), we reached a p-value of 0.013. In the logistic regression analysis baseline viral load >600.000 IU/ml (p < 001), IL28B rs8099917/rs12979860 TT/CC (p < 0.001), NT5 (gene encoding for 5' nucleotidase) 153 TC (p = 0.012) and ABCB1 3435 CT/TT (p = 0.034) genotypes predicted MC presence. Conclusion: These data could help clinicians to identify patients with higher probability to show MC extra hepatic complication.

Lingua originale	Inglese
pagine (da-a)	607-611
Numero di pagine	5
Rivista	Pharmacogenomics
Volume	18
Numero di pubblicazione	7
DOI	https://doi.org/10.2217/pgs-2016-0040
Stato di pubblicazione	Pubblicato - mag 2017
Pubblicato esternamente	Sì

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.2217/pgs-2016-0040

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{7f38ac5e123e4d478e3c5344bd12ce17,

title = "Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia",

abstract = "Aim: Mixed cryoglobulinemia (MC) is an extra hepatic hepatitis C virus related problem and different studies suggested genetics' role in predicting this complication. We evaluated the influence of SNPs in IL-28B, SLC29A1, SLC28A2, NT5C2, HNF4 and ABCB1 genes in MC prediction. Patients & methods: SNPs were evaluated through real-time PCR. Results: ABCB1 (gene encoding P-glycoprotein) 3435C>T SNP was associated with MC presence (p = 0.034): related to T allele carriers (CC vs CT/TT), we reached a p-value of 0.013. In the logistic regression analysis baseline viral load >600.000 IU/ml (p < 001), IL28B rs8099917/rs12979860 TT/CC (p < 0.001), NT5 (gene encoding for 5' nucleotidase) 153 TC (p = 0.012) and ABCB1 3435 CT/TT (p = 0.034) genotypes predicted MC presence. Conclusion: These data could help clinicians to identify patients with higher probability to show MC extra hepatic complication.",

keywords = "ABCB1, HCV, HCV extra hepatic manifestation, NT5, cryoglobulin, pegylated interferon/ribavirin, pharmacogenetics SNPs",

author = "Jessica Cusato and Lucio Boglione and {De Nicol{\`o}}, Amedeo and Cardellino, {Chiara Simona} and Chiara Carcieri and Giuseppe Cariti and {Di Perri}, Giovanni and Antonio D'Avolio",

note = "Publisher Copyright: {\textcopyright} 2017 Future Medicine Ltd.",

year = "2017",

month = may,

doi = "10.2217/pgs-2016-0040",

language = "English",

volume = "18",

pages = "607--611",

journal = "Pharmacogenomics",

issn = "1462-2416",

publisher = "Taylor and Francis Ltd.",

number = "7",

}

TY - JOUR

T1 - Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia

AU - Cusato, Jessica

AU - Boglione, Lucio

AU - De Nicolò, Amedeo

AU - Cardellino, Chiara Simona

AU - Carcieri, Chiara

AU - Cariti, Giuseppe

AU - Di Perri, Giovanni

AU - D'Avolio, Antonio

PY - 2017/5

Y1 - 2017/5

N2 - Aim: Mixed cryoglobulinemia (MC) is an extra hepatic hepatitis C virus related problem and different studies suggested genetics' role in predicting this complication. We evaluated the influence of SNPs in IL-28B, SLC29A1, SLC28A2, NT5C2, HNF4 and ABCB1 genes in MC prediction. Patients & methods: SNPs were evaluated through real-time PCR. Results: ABCB1 (gene encoding P-glycoprotein) 3435C>T SNP was associated with MC presence (p = 0.034): related to T allele carriers (CC vs CT/TT), we reached a p-value of 0.013. In the logistic regression analysis baseline viral load >600.000 IU/ml (p < 001), IL28B rs8099917/rs12979860 TT/CC (p < 0.001), NT5 (gene encoding for 5' nucleotidase) 153 TC (p = 0.012) and ABCB1 3435 CT/TT (p = 0.034) genotypes predicted MC presence. Conclusion: These data could help clinicians to identify patients with higher probability to show MC extra hepatic complication.

AB - Aim: Mixed cryoglobulinemia (MC) is an extra hepatic hepatitis C virus related problem and different studies suggested genetics' role in predicting this complication. We evaluated the influence of SNPs in IL-28B, SLC29A1, SLC28A2, NT5C2, HNF4 and ABCB1 genes in MC prediction. Patients & methods: SNPs were evaluated through real-time PCR. Results: ABCB1 (gene encoding P-glycoprotein) 3435C>T SNP was associated with MC presence (p = 0.034): related to T allele carriers (CC vs CT/TT), we reached a p-value of 0.013. In the logistic regression analysis baseline viral load >600.000 IU/ml (p < 001), IL28B rs8099917/rs12979860 TT/CC (p < 0.001), NT5 (gene encoding for 5' nucleotidase) 153 TC (p = 0.012) and ABCB1 3435 CT/TT (p = 0.034) genotypes predicted MC presence. Conclusion: These data could help clinicians to identify patients with higher probability to show MC extra hepatic complication.

KW - ABCB1

KW - HCV

KW - HCV extra hepatic manifestation

KW - NT5

KW - cryoglobulin

KW - pegylated interferon/ribavirin

KW - pharmacogenetics SNPs

UR - http://www.scopus.com/inward/record.url?scp=85019946854&partnerID=8YFLogxK

U2 - 10.2217/pgs-2016-0040

DO - 10.2217/pgs-2016-0040

M3 - Article

SN - 1462-2416

VL - 18

SP - 607

EP - 611

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 7

ER -

Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia

Abstract

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo