Persistence of E2A/PBX1 transcripts in t(1;19) childhood acute lymphoblastic leukemia: Correlation with chemotherapy intensity and clinical outcome

Carlo Lanza; Enrico Gottardi; Gianluca Gaidano; Claudia Vivenza; Adele Parziale; Fatima Perfetto; Marinella Fornaci; Elena Barisone; Enrico Madon; Giuseppe Basso; Giuseppe Saglio

doi:10.1016/0145-2126(95)00115-8

Persistence of E2A/PBX1 transcripts in t(1;19) childhood acute lymphoblastic leukemia: Correlation with chemotherapy intensity and clinical outcome

Carlo Lanza, Enrico Gottardi, Gianluca Gaidano, Claudia Vivenza, Adele Parziale, Fatima Perfetto, Marinella Fornaci, Elena Barisone, Enrico Madon, Giuseppe Basso, Giuseppe Saglio

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The occurrence of t(1;19) translocation was investigated by reverse transcriptase-polymerase chain reaction (RT-PCR) for the E2A/PBX1 hybrid message in a panel of 37 consecutive childhood acute lymphoblastic leukemias (ALLs). Three patients with B-precursor ALL were found to be positive at diagnosis and were re-tested during follow-up to assess the presence of minimal residual disease (MRD). Two of them became PCR-negative during treatment, whereas one remains positive 3 years after diagnosis. Since all three patients are presently in clinical and hematological complete remission, PCR detection of persistent E2A/PBX1 transcript does not seem to affect significantly the DFS at 3 years. However, the predictivity for an eventual late relapse still remains to be assessed.

Lingua originale	Inglese
pagine (da-a)	441-443
Numero di pagine	3
Rivista	Leukemia Research
Volume	20
Numero di pubblicazione	5
DOI	https://doi.org/10.1016/0145-2126(95)00115-8
Stato di pubblicazione	Pubblicato - mag 1996
Pubblicato esternamente	Sì

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Lanza, C., Gottardi, E., Gaidano, G., Vivenza, C., Parziale, A., Perfetto, F., Fornaci, M., Barisone, E., Madon, E., Basso, G., & Saglio, G. (1996). Persistence of E2A/PBX1 transcripts in t(1;19) childhood acute lymphoblastic leukemia: Correlation with chemotherapy intensity and clinical outcome. Leukemia Research, 20(5), 441-443. https://doi.org/10.1016/0145-2126(95)00115-8

@article{ba7336742fe64f53a216cc8736096bc0,

title = "Persistence of E2A/PBX1 transcripts in t(1;19) childhood acute lymphoblastic leukemia: Correlation with chemotherapy intensity and clinical outcome",

abstract = "The occurrence of t(1;19) translocation was investigated by reverse transcriptase-polymerase chain reaction (RT-PCR) for the E2A/PBX1 hybrid message in a panel of 37 consecutive childhood acute lymphoblastic leukemias (ALLs). Three patients with B-precursor ALL were found to be positive at diagnosis and were re-tested during follow-up to assess the presence of minimal residual disease (MRD). Two of them became PCR-negative during treatment, whereas one remains positive 3 years after diagnosis. Since all three patients are presently in clinical and hematological complete remission, PCR detection of persistent E2A/PBX1 transcript does not seem to affect significantly the DFS at 3 years. However, the predictivity for an eventual late relapse still remains to be assessed.",

keywords = "ALL, Childhood, E2A/PBX1, MRD, PCR, t(1;19)",

author = "Carlo Lanza and Enrico Gottardi and Gianluca Gaidano and Claudia Vivenza and Adele Parziale and Fatima Perfetto and Marinella Fornaci and Elena Barisone and Enrico Madon and Giuseppe Basso and Giuseppe Saglio",

note = "Funding Information: Acknowledgements-This work has been supported by AIRC (Associazione Italiana per la Ricerca sul Cancro) and by CNR PR ACRO grant No. 94.01205.PF.39. C. L. is sponsored by a Gigi Ghirotti fellowship. This work has been partly supported by the Compagnia di San Paolo. We are indebted to Mrs Mary Lobianco for reviewing the English language of the manuscript.",

year = "1996",

month = may,

doi = "10.1016/0145-2126(95)00115-8",

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volume = "20",

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journal = "Leukemia Research",

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Lanza, C, Gottardi, E, Gaidano, G, Vivenza, C, Parziale, A, Perfetto, F, Fornaci, M, Barisone, E, Madon, E, Basso, G & Saglio, G 1996, 'Persistence of E2A/PBX1 transcripts in t(1;19) childhood acute lymphoblastic leukemia: Correlation with chemotherapy intensity and clinical outcome', Leukemia Research, vol. 20, n. 5, pagg. 441-443. https://doi.org/10.1016/0145-2126(95)00115-8

TY - JOUR

T1 - Persistence of E2A/PBX1 transcripts in t(1;19) childhood acute lymphoblastic leukemia

T2 - Correlation with chemotherapy intensity and clinical outcome

AU - Lanza, Carlo

AU - Gottardi, Enrico

AU - Gaidano, Gianluca

AU - Vivenza, Claudia

AU - Parziale, Adele

AU - Perfetto, Fatima

AU - Fornaci, Marinella

AU - Barisone, Elena

AU - Madon, Enrico

AU - Basso, Giuseppe

AU - Saglio, Giuseppe

N1 - Funding Information: Acknowledgements-This work has been supported by AIRC (Associazione Italiana per la Ricerca sul Cancro) and by CNR PR ACRO grant No. 94.01205.PF.39. C. L. is sponsored by a Gigi Ghirotti fellowship. This work has been partly supported by the Compagnia di San Paolo. We are indebted to Mrs Mary Lobianco for reviewing the English language of the manuscript.

PY - 1996/5

Y1 - 1996/5

N2 - The occurrence of t(1;19) translocation was investigated by reverse transcriptase-polymerase chain reaction (RT-PCR) for the E2A/PBX1 hybrid message in a panel of 37 consecutive childhood acute lymphoblastic leukemias (ALLs). Three patients with B-precursor ALL were found to be positive at diagnosis and were re-tested during follow-up to assess the presence of minimal residual disease (MRD). Two of them became PCR-negative during treatment, whereas one remains positive 3 years after diagnosis. Since all three patients are presently in clinical and hematological complete remission, PCR detection of persistent E2A/PBX1 transcript does not seem to affect significantly the DFS at 3 years. However, the predictivity for an eventual late relapse still remains to be assessed.

AB - The occurrence of t(1;19) translocation was investigated by reverse transcriptase-polymerase chain reaction (RT-PCR) for the E2A/PBX1 hybrid message in a panel of 37 consecutive childhood acute lymphoblastic leukemias (ALLs). Three patients with B-precursor ALL were found to be positive at diagnosis and were re-tested during follow-up to assess the presence of minimal residual disease (MRD). Two of them became PCR-negative during treatment, whereas one remains positive 3 years after diagnosis. Since all three patients are presently in clinical and hematological complete remission, PCR detection of persistent E2A/PBX1 transcript does not seem to affect significantly the DFS at 3 years. However, the predictivity for an eventual late relapse still remains to be assessed.

KW - ALL

KW - Childhood

KW - E2A/PBX1

KW - MRD

KW - PCR

KW - t(1;19)

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U2 - 10.1016/0145-2126(95)00115-8

DO - 10.1016/0145-2126(95)00115-8

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SN - 0145-2126

VL - 20

SP - 441

EP - 443

JO - Leukemia Research

JF - Leukemia Research

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ER -

Persistence of E2A/PBX1 transcripts in t(1;19) childhood acute lymphoblastic leukemia: Correlation with chemotherapy intensity and clinical outcome

Abstract

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