Abstract
Cannabinoids are a complex group of molecules that comprise phytocannabinoids, endocannabinoids, and synthetic cannabinoids. Cannabinoids were initially identified by their ability to bind and activate the classical cannabinoid receptors CB1 and CB2. However, cannabinoids are pleiotropic in nature, and also activate other type of receptors, such as transient receptor potential cation channels, ligand-gated ion channels, deorphanized G protein coupled receptors, and peroxisome proliferator activated receptors such as PPAR?. Thus, cannabinoids may exert their biological activities through CB1/CB2-dependent and independent mechanisms, or a combination of both, which is especially relevant in the case of botanical drugs containing mixtures of phytocannabinoids. PPAR? exerts a wide variety of physiological functions, and its pharmacological manipulation has been exploited for the treatment of diabetes. In addition, PPAR? is recognized as a major target for the development of novel therapies aimed at managing chronic inflammatory and neurodegenerative diseases. Here, we review the published literature on cannabinoids and PPAR?, and discuss their potential therapeutic implications.
Lingua originale | Inglese |
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Titolo della pubblicazione ospite | Handbook of Cannabis and Related Pathologies |
Sottotitolo della pubblicazione ospite | Biology, Pharmacology, Diagnosis, and Treatment |
Editore | Elsevier Inc. |
Pagine | 671-679 |
Numero di pagine | 9 |
ISBN (elettronico) | 9780128008270 |
ISBN (stampa) | 9780128007563 |
DOI | |
Stato di pubblicazione | Pubblicato - 24 gen 2017 |