Peripheral nerve vascular changes in spontaneously hypertensive rats

Maurizio Sabbatini, Josè Antonio Vega, Francesco Amenta

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Circulation to the brain is affected by hypertension. Hypertension-dependent cerebrovascular changes were documented primarily in brain pial arteries, whereas no information is so far available concerning changes of peripheral nerve vascularization in hypertension. This study was designed to assess the occurrence of structural changes of interfascicular and intrafascicular arteries supplying peripheral nerves (the so called vasa nervorum) in spontaneously hypertensive rats (SHR). The investigation was performed in 8-month-old SHR, by using standard microanatomical techniques associated with quantitative image analysis. In SHR a significant increase of systolic pressure values accompanied by thickening of the arterial wall, narrowing of the lumen and increase of the wall-to-lumen ratio were observed in comparison with age-matched normotensive Wistar-Kyoto rats. Hypertension-related structural changes involved primarily interfascicular arteries and to a lesser extent intrafascicular arteries. These findings indicate that similarly as documented for cerebral arteries, the vascular supply to peripheral nerves is impaired in hypertension. Structural changes of interfascicular and intrafascicular arteries of SHR could lead to ischemia of peripheral nerves. Further work is in progress to evaluate the functional relevance of hypertensive changes to peripheral nerve vasculature.

Lingua originaleInglese
pagine (da-a)85-88
Numero di pagine4
RivistaNeuroscience Letters
Volume217
Numero di pubblicazione2-3
DOI
Stato di pubblicazionePubblicato - 18 ott 1996
Pubblicato esternamente

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