Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study

Yasmin Lassen-Ramshad; Enis Ozyar; Senem Alanyali; Philip Poortmans; Paul van Houtte; Schoeb Sohawon; Mustafa Esassolak; Marco Krengli; Salvador Villa; Robert Miller; Candan Demiroz; Serap Akyurek; Ninna Aggerholm-Pedersen; Juliette Thariat

doi:10.1002/hed.25611

Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study

Yasmin Lassen-Ramshad, Enis Ozyar, Senem Alanyali, Philip Poortmans, Paul van Houtte, Schoeb Sohawon, Mustafa Esassolak, Marco Krengli, Salvador Villa, Robert Miller, Candan Demiroz, Serap Akyurek, Ninna Aggerholm-Pedersen, Juliette Thariat

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Background: Paraganglioma of the head and neck (HNPGL) are rare often benign tumors. Surgery and radiation therapy (RT) are the main treatment choices. We present an analysis of outcome and toxicity after RT from 13 institutions of the Rare Cancer Network. Methods: Data were collected using a questionnaire concerning patients' characteristics, treatment, and outcome. A total of 81 patients with 82 HNPGL were analyzed. Results: The median follow-up was 48 months (1-456). Sixty-two lesions were treated with conventional RT and 20 lesions with stereotactic RT. Local control (LC) was achieved in 69 out of 77 lesions. Late toxicity occurred in 17 patients. Patients treated with stereotactic RT experienced neither disease progression nor late toxicity. Four patients with a follow-up longer than 20 years experienced disease progression. Conclusion: RT for HNPGL offered good local control with acceptable toxicity. Stereotactic RT might offer better results. Long-term follow-up is required.

Lingua originale	Inglese
pagine (da-a)	1770-1776
Numero di pagine	7
Rivista	Head and Neck
Volume	41
Numero di pubblicazione	6
DOI	https://doi.org/10.1002/hed.25611
Stato di pubblicazione	Pubblicato - giu 2019

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Lassen-Ramshad, Y., Ozyar, E., Alanyali, S., Poortmans, P., van Houtte, P., Sohawon, S., Esassolak, M., Krengli, M., Villa, S., Miller, R., Demiroz, C., Akyurek, S., Aggerholm-Pedersen, N., & Thariat, J. (2019). Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study. Head and Neck, 41(6), 1770-1776. https://doi.org/10.1002/hed.25611

@article{7e2d0a6f684b4bd69dff4573382d1871,

title = "Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study",

abstract = "Background: Paraganglioma of the head and neck (HNPGL) are rare often benign tumors. Surgery and radiation therapy (RT) are the main treatment choices. We present an analysis of outcome and toxicity after RT from 13 institutions of the Rare Cancer Network. Methods: Data were collected using a questionnaire concerning patients' characteristics, treatment, and outcome. A total of 81 patients with 82 HNPGL were analyzed. Results: The median follow-up was 48 months (1-456). Sixty-two lesions were treated with conventional RT and 20 lesions with stereotactic RT. Local control (LC) was achieved in 69 out of 77 lesions. Late toxicity occurred in 17 patients. Patients treated with stereotactic RT experienced neither disease progression nor late toxicity. Four patients with a follow-up longer than 20 years experienced disease progression. Conclusion: RT for HNPGL offered good local control with acceptable toxicity. Stereotactic RT might offer better results. Long-term follow-up is required.",

author = "Yasmin Lassen-Ramshad and Enis Ozyar and Senem Alanyali and Philip Poortmans and {van Houtte}, Paul and Schoeb Sohawon and Mustafa Esassolak and Marco Krengli and Salvador Villa and Robert Miller and Candan Demiroz and Serap Akyurek and Ninna Aggerholm-Pedersen and Juliette Thariat",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

month = jun,

doi = "10.1002/hed.25611",

language = "English",

volume = "41",

pages = "1770--1776",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

number = "6",

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Lassen-Ramshad, Y, Ozyar, E, Alanyali, S, Poortmans, P, van Houtte, P, Sohawon, S, Esassolak, M, Krengli, M, Villa, S, Miller, R, Demiroz, C, Akyurek, S, Aggerholm-Pedersen, N & Thariat, J 2019, 'Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study', Head and Neck, vol. 41, n. 6, pagg. 1770-1776. https://doi.org/10.1002/hed.25611

TY - JOUR

T1 - Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study

AU - Lassen-Ramshad, Yasmin

AU - Ozyar, Enis

AU - Alanyali, Senem

AU - Poortmans, Philip

AU - van Houtte, Paul

AU - Sohawon, Schoeb

AU - Esassolak, Mustafa

AU - Krengli, Marco

AU - Villa, Salvador

AU - Miller, Robert

AU - Demiroz, Candan

AU - Akyurek, Serap

AU - Aggerholm-Pedersen, Ninna

AU - Thariat, Juliette

PY - 2019/6

Y1 - 2019/6

N2 - Background: Paraganglioma of the head and neck (HNPGL) are rare often benign tumors. Surgery and radiation therapy (RT) are the main treatment choices. We present an analysis of outcome and toxicity after RT from 13 institutions of the Rare Cancer Network. Methods: Data were collected using a questionnaire concerning patients' characteristics, treatment, and outcome. A total of 81 patients with 82 HNPGL were analyzed. Results: The median follow-up was 48 months (1-456). Sixty-two lesions were treated with conventional RT and 20 lesions with stereotactic RT. Local control (LC) was achieved in 69 out of 77 lesions. Late toxicity occurred in 17 patients. Patients treated with stereotactic RT experienced neither disease progression nor late toxicity. Four patients with a follow-up longer than 20 years experienced disease progression. Conclusion: RT for HNPGL offered good local control with acceptable toxicity. Stereotactic RT might offer better results. Long-term follow-up is required.

AB - Background: Paraganglioma of the head and neck (HNPGL) are rare often benign tumors. Surgery and radiation therapy (RT) are the main treatment choices. We present an analysis of outcome and toxicity after RT from 13 institutions of the Rare Cancer Network. Methods: Data were collected using a questionnaire concerning patients' characteristics, treatment, and outcome. A total of 81 patients with 82 HNPGL were analyzed. Results: The median follow-up was 48 months (1-456). Sixty-two lesions were treated with conventional RT and 20 lesions with stereotactic RT. Local control (LC) was achieved in 69 out of 77 lesions. Late toxicity occurred in 17 patients. Patients treated with stereotactic RT experienced neither disease progression nor late toxicity. Four patients with a follow-up longer than 20 years experienced disease progression. Conclusion: RT for HNPGL offered good local control with acceptable toxicity. Stereotactic RT might offer better results. Long-term follow-up is required.

UR - http://www.scopus.com/inward/record.url?scp=85059880384&partnerID=8YFLogxK

U2 - 10.1002/hed.25611

DO - 10.1002/hed.25611

M3 - Article

SN - 1043-3074

VL - 41

SP - 1770

EP - 1776

JO - Head and Neck

JF - Head and Neck

IS - 6

ER -

Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study

Abstract

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