TY - JOUR
T1 - Pain and Frailty in Hospitalized Older Adults
AU - REPOSI Investigators
AU - Ardoino, Ilaria
AU - Franchi, Carlotta
AU - Nobili, Alessandro
AU - Mannucci, Pier Mannuccio
AU - Corli, Oscar
AU - Pietrangelo, Antonello
AU - Perticone, Francesco
AU - Licata, Giuseppe
AU - Violi, Francesco
AU - Corazza, Gino Roberto
AU - Corrao, Salvatore
AU - Marengoni, Alessandra
AU - Salerno, Francesco
AU - Cesari, Matteo
AU - Tettamanti, Mauro
AU - Pasina, Luca
AU - Franchi, Carlotta
AU - Franchi, Carlotta
AU - Cortesi, Laura
AU - Miglio, Gabriella
AU - Cortesi, Laura
AU - Novella, Alessio
AU - Prisco, Domenico
AU - Silvestri, Elena
AU - Emmi, Giacomo
AU - Bettiol, Alessandra
AU - Mattioli, Irene
AU - Biolo, Gianni
AU - Zanetti, Michela
AU - Bartelloni, Giacomo
AU - Vanoli, Massimo
AU - Grignani, Giulia
AU - Pulixi, Edoardo Alessandro
AU - Lupattelli, Graziana
AU - Bianconi, Vanessa
AU - Alcidi, Riccardo
AU - Girelli, Domenico
AU - Busti, Fabiana
AU - Marchi, Giacomo
AU - Barbagallo, Mario
AU - Dominguez, Ligia
AU - Beneduce, Vincenza
AU - Cacioppo, Federica
AU - Natoli, Giuseppe
AU - Mularo, Salvatore
AU - Raspanti, Massimo
AU - Zoli, Marco
AU - Pirisi, Mario
AU - Sola, Daniele
AU - Bellan, Mattia
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Introduction: Pain and frailty are prevalent conditions in the older population. Many chronic diseases are likely involved in their origin, and both have a negative impact on quality of life. However, few studies have analysed their association. Methods: In light of this knowledge gap, 3577 acutely hospitalized patients 65 years or older enrolled in the REPOSI register, an Italian network of internal medicine and geriatric hospital wards, were assessed to calculate the frailty index (FI). The impact of pain and some of its characteristics on the degree of frailty was evaluated using an ordinal logistic regression model after adjusting for age and gender. Results: The prevalence of pain was 24.7%, and among patients with pain, 42.9% was regarded as chronic pain. Chronic pain was associated with severe frailty (OR = 1.69, 95% CI 1.38–2.07). Somatic pain (OR = 1.59, 95% CI 1.23–2.07) and widespread pain (OR = 1.60, 95% CI 0.93–2.78) were associated with frailty. Osteoarthritis was the most common cause of chronic pain, diagnosed in 157 patients (33.5%). Polymyalgia, rheumatoid arthritis and other musculoskeletal diseases causing chronic pain were associated with a lower degree of frailty than osteoarthritis (OR = 0.49, 95%CI 0.28–0.85). Conclusions: Chronic and somatic pain negatively affect the degree of frailty. The duration and type of pain, as well as the underlying diseases associated with chronic pain, should be evaluated to improve the hospital management of frail older people.
AB - Introduction: Pain and frailty are prevalent conditions in the older population. Many chronic diseases are likely involved in their origin, and both have a negative impact on quality of life. However, few studies have analysed their association. Methods: In light of this knowledge gap, 3577 acutely hospitalized patients 65 years or older enrolled in the REPOSI register, an Italian network of internal medicine and geriatric hospital wards, were assessed to calculate the frailty index (FI). The impact of pain and some of its characteristics on the degree of frailty was evaluated using an ordinal logistic regression model after adjusting for age and gender. Results: The prevalence of pain was 24.7%, and among patients with pain, 42.9% was regarded as chronic pain. Chronic pain was associated with severe frailty (OR = 1.69, 95% CI 1.38–2.07). Somatic pain (OR = 1.59, 95% CI 1.23–2.07) and widespread pain (OR = 1.60, 95% CI 0.93–2.78) were associated with frailty. Osteoarthritis was the most common cause of chronic pain, diagnosed in 157 patients (33.5%). Polymyalgia, rheumatoid arthritis and other musculoskeletal diseases causing chronic pain were associated with a lower degree of frailty than osteoarthritis (OR = 0.49, 95%CI 0.28–0.85). Conclusions: Chronic and somatic pain negatively affect the degree of frailty. The duration and type of pain, as well as the underlying diseases associated with chronic pain, should be evaluated to improve the hospital management of frail older people.
KW - Chronic pain
KW - Internal medicine and geriatric wards
KW - Musculoskeletal diseases
UR - http://www.scopus.com/inward/record.url?scp=85102782089&partnerID=8YFLogxK
U2 - 10.1007/s40122-020-00202-3
DO - 10.1007/s40122-020-00202-3
M3 - Review article
SN - 2193-8237
VL - 9
SP - 727
EP - 740
JO - Pain and Therapy
JF - Pain and Therapy
IS - 2
ER -