Paclitaxel analogues from Taxus x media cv. Hicksii

Bruno Gabetta; Nicola Fuzzati; Paolo Orsini; Federico Peterlongo; Giovanni Appendino; David G. Vander Velde

doi:10.1021/np9802264

Paclitaxel analogues from Taxus x media cv. Hicksii

Bruno Gabetta
, Nicola Fuzzati
, Paolo Orsini
, Federico Peterlongo
, Giovanni Appendino
, David G. Vander Velde

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The roots of T. x media Rehd. cv. Hicksii gave three novel analogues of paclitaxel modified at the N-acyl residue (N-debenzoyl-N-α-methylbutyryl paclitaxel and N-debenzoyl-N-cinnamoyl paclitaxel, 1b and 1c, respectively) or at the ester group at C-2 (2-debenzoyl-2-tigloyl paclitaxel, 1d). Compounds 1b and 1d showed reduced cytotoxicity and tubulin binding compared to paclitaxel, while 1c retained substantial activity in these assays.

Lingua originale	Inglese
pagine (da-a)	219-223
Numero di pagine	5
Rivista	Journal of Natural Products
Volume	62
Numero di pubblicazione	2
DOI	https://doi.org/10.1021/np9802264
Stato di pubblicazione	Pubblicato - feb 1999
Pubblicato esternamente	Sì

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10.1021/np9802264

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title = "Paclitaxel analogues from Taxus x media cv. Hicksii",

abstract = "The roots of T. x media Rehd. cv. Hicksii gave three novel analogues of paclitaxel modified at the N-acyl residue (N-debenzoyl-N-α-methylbutyryl paclitaxel and N-debenzoyl-N-cinnamoyl paclitaxel, 1b and 1c, respectively) or at the ester group at C-2 (2-debenzoyl-2-tigloyl paclitaxel, 1d). Compounds 1b and 1d showed reduced cytotoxicity and tubulin binding compared to paclitaxel, while 1c retained substantial activity in these assays.",

author = "Bruno Gabetta and Nicola Fuzzati and Paolo Orsini and Federico Peterlongo and Giovanni Appendino and \{Vander Velde\}, \{David G.\}",

year = "1999",

month = feb,

doi = "10.1021/np9802264",

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pages = "219--223",

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T1 - Paclitaxel analogues from Taxus x media cv. Hicksii

AU - Gabetta, Bruno

AU - Fuzzati, Nicola

AU - Orsini, Paolo

AU - Peterlongo, Federico

AU - Appendino, Giovanni

AU - Vander Velde, David G.

PY - 1999/2

Y1 - 1999/2

N2 - The roots of T. x media Rehd. cv. Hicksii gave three novel analogues of paclitaxel modified at the N-acyl residue (N-debenzoyl-N-α-methylbutyryl paclitaxel and N-debenzoyl-N-cinnamoyl paclitaxel, 1b and 1c, respectively) or at the ester group at C-2 (2-debenzoyl-2-tigloyl paclitaxel, 1d). Compounds 1b and 1d showed reduced cytotoxicity and tubulin binding compared to paclitaxel, while 1c retained substantial activity in these assays.

AB - The roots of T. x media Rehd. cv. Hicksii gave three novel analogues of paclitaxel modified at the N-acyl residue (N-debenzoyl-N-α-methylbutyryl paclitaxel and N-debenzoyl-N-cinnamoyl paclitaxel, 1b and 1c, respectively) or at the ester group at C-2 (2-debenzoyl-2-tigloyl paclitaxel, 1d). Compounds 1b and 1d showed reduced cytotoxicity and tubulin binding compared to paclitaxel, while 1c retained substantial activity in these assays.

UR - https://www.scopus.com/pages/publications/0033058548

U2 - 10.1021/np9802264

DO - 10.1021/np9802264

M3 - Article

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VL - 62

SP - 219

EP - 223

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 2

ER -

Paclitaxel analogues from Taxus x media cv. Hicksii

Abstract

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