TY - JOUR
T1 - Paclitaxel analogues from Taxus x media cv. Hicksii
AU - Gabetta, Bruno
AU - Fuzzati, Nicola
AU - Orsini, Paolo
AU - Peterlongo, Federico
AU - Appendino, Giovanni
AU - Vander Velde, David G.
PY - 1999/2
Y1 - 1999/2
N2 - The roots of T. x media Rehd. cv. Hicksii gave three novel analogues of paclitaxel modified at the N-acyl residue (N-debenzoyl-N-α-methylbutyryl paclitaxel and N-debenzoyl-N-cinnamoyl paclitaxel, 1b and 1c, respectively) or at the ester group at C-2 (2-debenzoyl-2-tigloyl paclitaxel, 1d). Compounds 1b and 1d showed reduced cytotoxicity and tubulin binding compared to paclitaxel, while 1c retained substantial activity in these assays.
AB - The roots of T. x media Rehd. cv. Hicksii gave three novel analogues of paclitaxel modified at the N-acyl residue (N-debenzoyl-N-α-methylbutyryl paclitaxel and N-debenzoyl-N-cinnamoyl paclitaxel, 1b and 1c, respectively) or at the ester group at C-2 (2-debenzoyl-2-tigloyl paclitaxel, 1d). Compounds 1b and 1d showed reduced cytotoxicity and tubulin binding compared to paclitaxel, while 1c retained substantial activity in these assays.
UR - http://www.scopus.com/inward/record.url?scp=0033058548&partnerID=8YFLogxK
U2 - 10.1021/np9802264
DO - 10.1021/np9802264
M3 - Article
SN - 0163-3864
VL - 62
SP - 219
EP - 223
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 2
ER -