TY - JOUR
T1 - Osteopontin is increased in the cerebrospinal fluid of patients with Alzheimer's disease and its levels correlate with cognitive decline
AU - Comi, Cristoforo
AU - Carecchio, Miryam
AU - Chiocchetti, Annalisa
AU - Nicola, Stefania
AU - Galimberti, Daniela
AU - Fenoglio, Chiara
AU - Cappellano, Giuseppe
AU - Monaco, Francesco
AU - Scarpini, Elio
AU - Dianzani, Umberto
PY - 2010
Y1 - 2010
N2 - Inflammation is believed to play a role in Alzheimer's disease (AD). Osteopontin (OPN) is a molecule involved in macrophage recruitment and activation and implicated in neurodegeneration. In order to elucidate the role of OPN in AD, we evaluated its levels in serum and cerebrospinal fluid (CSF) of 67 AD patients, 46 frontotemporal dementia (FTD) patients, and 69 controls. We found that OPN levels: i) are significantly increased in the CSF of AD patients; ii) correlate with MMSE score; and iii) are higher in the early disease phases (≤ 2 years). These findings support a role of OPN in AD pathogenesis.
AB - Inflammation is believed to play a role in Alzheimer's disease (AD). Osteopontin (OPN) is a molecule involved in macrophage recruitment and activation and implicated in neurodegeneration. In order to elucidate the role of OPN in AD, we evaluated its levels in serum and cerebrospinal fluid (CSF) of 67 AD patients, 46 frontotemporal dementia (FTD) patients, and 69 controls. We found that OPN levels: i) are significantly increased in the CSF of AD patients; ii) correlate with MMSE score; and iii) are higher in the early disease phases (≤ 2 years). These findings support a role of OPN in AD pathogenesis.
KW - Disease progression
KW - Early Alzheimer's disease
KW - Eta-1
KW - Microglia
KW - Neuroinflammation
UR - http://www.scopus.com/inward/record.url?scp=77950356481&partnerID=8YFLogxK
U2 - 10.3233/JAD-2010-1309
DO - 10.3233/JAD-2010-1309
M3 - Article
SN - 1387-2877
VL - 19
SP - 1143
EP - 1148
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 4
ER -
