TY - JOUR
T1 - Organoids
T2 - a systematic review of ethical issues
AU - the VANGUARD consortium
AU - de Jongh, Dide
AU - Massey, Emma K.
AU - Berishvili, Ekaterine
AU - Fonseca, Laura Mar
AU - Lebreton, Fanny
AU - Bellofatto, Kevin
AU - Bignard, Juliette
AU - Seissler, Jochen
AU - Buerck, Leila Wolf van
AU - Honarpisheh, Mohsen
AU - Zhang, Yichen
AU - Lei, Yutian
AU - Pehl, Monika
AU - Follenzi, Antonia
AU - Olgasi, Christina
AU - Cucci, Alessia
AU - Borsotti, Chiara
AU - Assanelli, Simone
AU - Piemonti, Lorenzo
AU - Citro, Antonio
AU - Pellegrini, Silvia
AU - Pignatelli, Cataldo
AU - Campo, Francesco
AU - Thaunat, Olivier
AU - Cronin, Antonia J.
AU - Mey, Devi
AU - Parisotto, Chiara
AU - Rossi, Giovanna
AU - Kugelmeier, Patrick
AU - Wolint, Petra
AU - Mühlemann, Markus
AU - Pal-Kutas, Karolina
AU - Cavallaro, Marco
AU - Götz, Julia
AU - Müller, Jeanette
AU - Bunnik, Eline M.
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and clinical care. However, organoids are not seen as morally neutral. For instance, tissue donors may perceive enduring personal connections with their organoids, setting higher bars for informed consent and patient participation. Also, several organoid sub-types, e.g., brain organoids and human–animal chimeric organoids, have raised controversy. This systematic review provides an overview of ethical discussions as conducted in the scientific literature on organoids. The review covers both research and clinical applications of organoid technology and discusses the topics informed consent, commercialization, personalized medicine, transplantation, brain organoids, chimeras, and gastruloids. It shows that further ethical research is needed especially on organoid transplantation, to help ensure the responsible development and clinical implementation of this technology in this field.
AB - Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and clinical care. However, organoids are not seen as morally neutral. For instance, tissue donors may perceive enduring personal connections with their organoids, setting higher bars for informed consent and patient participation. Also, several organoid sub-types, e.g., brain organoids and human–animal chimeric organoids, have raised controversy. This systematic review provides an overview of ethical discussions as conducted in the scientific literature on organoids. The review covers both research and clinical applications of organoid technology and discusses the topics informed consent, commercialization, personalized medicine, transplantation, brain organoids, chimeras, and gastruloids. It shows that further ethical research is needed especially on organoid transplantation, to help ensure the responsible development and clinical implementation of this technology in this field.
KW - Brain organoids
KW - Chimeras
KW - Ethics
KW - Gastruloids
KW - Informed consent
KW - Organoids
KW - Personalized medicine
KW - Research oversight
KW - Stem cell research
KW - Transplantation
UR - https://www.scopus.com/pages/publications/85134463213
U2 - 10.1186/s13287-022-02950-9
DO - 10.1186/s13287-022-02950-9
M3 - Review article
SN - 1757-6512
VL - 13
JO - Stem Cell Research and Therapy
JF - Stem Cell Research and Therapy
IS - 1
M1 - 337
ER -
SDG 3 Salute e benessere