TY - JOUR
T1 - Oral manifestations of langerhans cell histiocytosis in a pediatric population
T2 - A clinical and histological study of 8 patients
AU - Mortellaro, C.
AU - Pucci, A.
AU - Palmeri, A.
AU - Lucchina, A. Greco
AU - Berta, M.
AU - Celeste, A.
AU - Costantino, S.
AU - Del Prever, A. Brach
AU - Forni, M.
PY - 2006/5
Y1 - 2006/5
N2 - Langerhans Cell Histiocytosis is a rare and protean disease of unknown etiology, clinically characterized by single or multiple osteolytic and/or soft tissue lesions. Oral involvement may predate systemic manifestations or mimic infectious/inflammatory disorders. In the present series, oral involvement characterized eight cases of pediatric Langerhans Cell Histiocytosis and oral symptoms represented a very early sign of this disease in four patients. A careful clinical investigation and a proper histologic analysis were required for achieving a definite diagnosis and for confirming clinical suspicion of disease relapse. Immunohistochemistry, that nowadays represents a reliable and accessible ancillary histological technique, allowed the definite diagnosis in all cases of our series.
AB - Langerhans Cell Histiocytosis is a rare and protean disease of unknown etiology, clinically characterized by single or multiple osteolytic and/or soft tissue lesions. Oral involvement may predate systemic manifestations or mimic infectious/inflammatory disorders. In the present series, oral involvement characterized eight cases of pediatric Langerhans Cell Histiocytosis and oral symptoms represented a very early sign of this disease in four patients. A careful clinical investigation and a proper histologic analysis were required for achieving a definite diagnosis and for confirming clinical suspicion of disease relapse. Immunohistochemistry, that nowadays represents a reliable and accessible ancillary histological technique, allowed the definite diagnosis in all cases of our series.
KW - Childhood
KW - Histology
KW - Immunohistochemistry
KW - Langerhans cell histiocytosis
UR - http://www.scopus.com/inward/record.url?scp=33747624388&partnerID=8YFLogxK
U2 - 10.1097/00001665-200605000-00028
DO - 10.1097/00001665-200605000-00028
M3 - Article
SN - 1049-2275
VL - 17
SP - 552
EP - 556
JO - Journal of Craniofacial Surgery
JF - Journal of Craniofacial Surgery
IS - 3
ER -